The role of lipids in the brain

Amal D. Premarathna, Anura P. Jayasooriya, Andrew J. Sinclair

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

4 Citations (Scopus)


This chapter considers the role of lipids in the brain. The topic is covered from the point of view of the composition of the many different lipid classes and lipid molecular species found there. The heterogeneity of the brain regions is considered in terms of the lipid composition and function. Specific emphasis is placed on the role of different fatty acids in the brain, including the omega-3 (n-3) and omega-6 (n-6) fatty acids, such as docosahexaenoic acid and AA. How these fatty acids enter the brain from the systemic circulation and the role of diet versus endogenous synthesis is discussed. The impact of exogenous agents and events is covered in the final section, including ethanol, cholesterol and saturated fats, reactive oxygen species, traumatic brain injury, plasticizers, microparticulate plastics, and finally methyl mercury.

Original languageEnglish
Title of host publicationAdvances in Dietary Lipids and Human Health
EditorsDuo Li
Place of PublicationLondon UK
Number of pages24
ISBN (Electronic)9780128239148
ISBN (Print)9780128242193
Publication statusPublished - 2022


  • Biochemical mechanism
  • Biochemistry
  • Biochemistry methods
  • Biomolecules
  • Cell biology
  • Physiology

Cite this