The role of kallikrein-related peptidases in prostate cancer: Potential involvement in an epithelial to mesenchymal transition

Astrid K. Whitbread, Tara L. Veveris-Lowe, Mitchell G. Lawrence, David L. Nicol, Judith A. Clements

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33 Citations (Scopus)

Abstract

Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated that expression of PSA or KLK4, but not KLK2, in PC-3 prostate cancer cells changed the cellular morphology from epithelial to spindle-shaped, markedly reduced E-cadherin expression, increased vimentin expression and increased cellular migration. These changes are indicative of an epithelial to mesenchymal transition (EMT), a process important in embryonic development and cancer progression. The potential novel role of kallikrein-related peptidases in this process is the focus of this brief review.

Original languageEnglish
Pages (from-to)707-714
Number of pages8
JournalBiological Chemistry
Volume387
Issue number6
DOIs
Publication statusPublished - 1 Jun 2006
Externally publishedYes

Keywords

  • E-cadherin
  • EMT
  • KLK4
  • Migration
  • Prostate cancer
  • PSA

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