The role of intracoronary imaging in translational research

Nicholas J. Montarello, Adam J. Nelson, Johan Verjans, Stephen J. Nicholls, Peter J. Psaltis

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Atherosclerotic cardiovascular disease is a key public health concern worldwide and leading cause of morbidity, mortality and health economic costs. Understanding atherosclerotic plaque microstructure in relation to molecular mechanisms that underpin its initiation and progression is needed to provide the best chance of combating this disease. Evolving vessel wall-based, endovascular coronary imaging modalities, including intravascular ultrasound (IVUS), optical coherence tomography (OCT) and near-infrared spectroscopy (NIRS), used in isolation or as hybrid modalities, have been advanced to allow comprehensive visualization of the pathological substrate of coronary atherosclerosis and accurately measure temporal changes in both the vessel wall and plaque characteristics. This has helped further our appreciation of the natural history of coronary artery disease (CAD) and the risk for major adverse cardiovascular events (MACE), evaluate the responsiveness to conventional and experimental therapeutic interventions, and assist in guiding percutaneous coronary intervention (PCI). Here we review the use of different imaging modalities for these purposes and the lessons they have provided thus far.

Original languageEnglish
Pages (from-to)1480-1507
Number of pages28
JournalCardiovascular Diagnosis and Therapy
Volume10
Issue number5
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Coronary artery disease (CAD)
  • Intracoronary imaging
  • Intravascular ultrasound (IVUS)
  • Near-infrared spectroscopy (NIRS)
  • Optical coherence tomography (OCT)
  • Plaque imaging

Cite this