The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants

James Harris, Fiona A Sharp, Ed C Lavelle

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Adjuvants are essential for enhancing and directing immunity to vaccine antigens. Most adjuvants in clinical use are particulates, but how they drive innate and adaptive immune responses is unclear. A major recent advance was the demonstration that particulate adjuvants promote activation of the NLRP3 inflammasome. The mechanisms underlying this activation have been partly resolved and the role of NLRP3 in particulate adjuvant-induced adaptive immunity is currently the subject of intense interest.
Original languageEnglish
Pages (from-to)634 - 638
Number of pages5
JournalEuropean Journal of Immunology
Volume40
Issue number3
DOIs
Publication statusPublished - 2010

Cite this

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abstract = "Adjuvants are essential for enhancing and directing immunity to vaccine antigens. Most adjuvants in clinical use are particulates, but how they drive innate and adaptive immune responses is unclear. A major recent advance was the demonstration that particulate adjuvants promote activation of the NLRP3 inflammasome. The mechanisms underlying this activation have been partly resolved and the role of NLRP3 in particulate adjuvant-induced adaptive immunity is currently the subject of intense interest.",
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The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants. / Harris, James; Sharp, Fiona A; Lavelle, Ed C.

In: European Journal of Immunology, Vol. 40, No. 3, 2010, p. 634 - 638.

Research output: Contribution to journalArticleResearchpeer-review

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AB - Adjuvants are essential for enhancing and directing immunity to vaccine antigens. Most adjuvants in clinical use are particulates, but how they drive innate and adaptive immune responses is unclear. A major recent advance was the demonstration that particulate adjuvants promote activation of the NLRP3 inflammasome. The mechanisms underlying this activation have been partly resolved and the role of NLRP3 in particulate adjuvant-induced adaptive immunity is currently the subject of intense interest.

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