The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants

James Harris; Fiona A Sharp; Ed C Lavelle

doi:10.1002/eji.200940172

The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants

James Harris, Fiona A Sharp, Ed C Lavelle

Centre for Inflammatory Disease Monash Health

Research output: Contribution to journal › Article › Research › peer-review

42 Citations (Scopus)

Abstract

Adjuvants are essential for enhancing and directing immunity to vaccine antigens. Most adjuvants in clinical use are particulates, but how they drive innate and adaptive immune responses is unclear. A major recent advance was the demonstration that particulate adjuvants promote activation of the NLRP3 inflammasome. The mechanisms underlying this activation have been partly resolved and the role of NLRP3 in particulate adjuvant-induced adaptive immunity is currently the subject of intense interest.

Original language	English
Pages (from-to)	634 - 638
Number of pages	5
Journal	European Journal of Immunology
Volume	40
Issue number	3
DOIs	https://doi.org/10.1002/eji.200940172
Publication status	Published - 2010

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10.1002/eji.200940172

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abstract = "Adjuvants are essential for enhancing and directing immunity to vaccine antigens. Most adjuvants in clinical use are particulates, but how they drive innate and adaptive immune responses is unclear. A major recent advance was the demonstration that particulate adjuvants promote activation of the NLRP3 inflammasome. The mechanisms underlying this activation have been partly resolved and the role of NLRP3 in particulate adjuvant-induced adaptive immunity is currently the subject of intense interest.",

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AB - Adjuvants are essential for enhancing and directing immunity to vaccine antigens. Most adjuvants in clinical use are particulates, but how they drive innate and adaptive immune responses is unclear. A major recent advance was the demonstration that particulate adjuvants promote activation of the NLRP3 inflammasome. The mechanisms underlying this activation have been partly resolved and the role of NLRP3 in particulate adjuvant-induced adaptive immunity is currently the subject of intense interest.

UR - http://www.ncbi.nlm.nih.gov/pubmed/20201019

U2 - 10.1002/eji.200940172

DO - 10.1002/eji.200940172

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JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 3

ER -

The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants

Abstract

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