The role of host genetics in leishmaniasis

Anuratha Sakthianandeswaren, Simon J Foote, Emanuela Handman

Research output: Contribution to journalReview ArticleResearchpeer-review

69 Citations (Scopus)

Abstract

Leishmaniasis is one of the world's important infectious diseases. It is prevalent in tropical and subtropical regions of the world and endemic in 88 countries, with two million new cases of leishmaniasis reported annually. As a complex disease, the pathology of leishmaniasis varies and is determined by factors such as the environment, the insect vector, and parasite and host genetics. The contributing host genetics involve multiple genes; thus, the mouse model of leishmaniasis has been exploited extensively in an attempt to identify and dissect the contribution of disease modifier genes to pathogenesis. This review summarizes recent advances in the identification of genetic loci involved in the host response to Leishmania spp. in the mouse model and in the human situation. Crown

Original languageEnglish
Pages (from-to)383-391
Number of pages9
JournalTrends in Parasitology
Volume25
Issue number8
DOIs
Publication statusPublished - Aug 2009
Externally publishedYes

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