The role of ghrelin in neuroprotection after ischemic brain injury

Sarah J. Spencer, Alyson A. Miller, Zane B. Andrews

Research output: Contribution to journalReview ArticleResearchpeer-review

20 Citations (Scopus)


Ghrelin, a gastrointestinal peptide with a major role in regulating feeding and metabolism, has recently been investigated for its neuroprotective effects. In this review we discuss pre-clinical evidence suggesting ghrelin may be a useful therapeutic in protecting the brain against injury after ischemic stroke. Specifically, we will discuss evidence showing ghrelin administration can improve neuronal cell survival in animal models of focal cerebral ischemia, as well as rescue memory deficits. We will also discuss its proposed mechanisms of action, including anti-apoptotic and anti-inflammatory effects, and suggest ghrelin treatment may be a useful intervention after stroke in the clinic.

Original languageEnglish
Pages (from-to)344-359
Number of pages16
JournalBrain Sciences
Issue number1
Publication statusPublished - 1 Jan 2013


  • Apoptosis
  • Ghrelin
  • Inflammation
  • Neurodegeneration

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