The Role of ERα and ERβ in the Prostate: Insights from Genetic Models and Isoform-Selective Ligands

Stephen John McPherson; Stuart John Ellem; Vladamir Patchev; Karl-Heinrich Fritzemeier; Gail Petuna Risbridger

The Role of ERα and ERβ in the Prostate: Insights from Genetic Models and Isoform-Selective Ligands

Stephen John McPherson, Stuart John Ellem, Vladamir Patchev, Karl-Heinrich Fritzemeier, Gail Petuna Risbridger

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

Abstract

The multiple actions of estrogens on different cell types have not only intrigued endocrinology researchers but also inspired the development of selective estrogen receptor modulators, or SERMs, that modulate estrogen signaling in a cell type-specific manner. Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology to dissect the mechanisms of estrogen-regulated gene expression in target cells, from in vivo analyses using genetic models deficient in estrogen signaling and from synthetic estrogen receptor ligands with isoform- or pathway-selective activity. These advances, and their implications for clinical use, were discussed by leading researchers from industry and academia during an international symposium held in Berlin, 1-3 March 2006 and are featured in this volume.

Original language	English
Title of host publication	Tissue-Specific Estrogen Action Novel Mechanisms, Novel Ligands, Novel Therapies
Editors	K S Korach, T Wintermantel
Place of Publication	Germany
Publisher	Springer
Pages	131-148
Number of pages	18
Edition	1st
ISBN (Print)	9783540495475
Publication status	Published - 2007

Cite this

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title = "The Role of ERα and ERβ in the Prostate: Insights from Genetic Models and Isoform-Selective Ligands",

abstract = "The multiple actions of estrogens on different cell types have not only intrigued endocrinology researchers but also inspired the development of selective estrogen receptor modulators, or SERMs, that modulate estrogen signaling in a cell type-specific manner. Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology to dissect the mechanisms of estrogen-regulated gene expression in target cells, from in vivo analyses using genetic models deficient in estrogen signaling and from synthetic estrogen receptor ligands with isoform- or pathway-selective activity. These advances, and their implications for clinical use, were discussed by leading researchers from industry and academia during an international symposium held in Berlin, 1-3 March 2006 and are featured in this volume.",

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The Role of ERα and ERβ in the Prostate: Insights from Genetic Models and Isoform-Selective Ligands. / McPherson, Stephen John; Ellem, Stuart John; Patchev, Vladamir et al.
Tissue-Specific Estrogen Action Novel Mechanisms, Novel Ligands, Novel Therapies. ed. / K S Korach; T Wintermantel. 1st. ed. Germany: Springer, 2007. p. 131-148.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

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AU - Risbridger, Gail Petuna

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AB - The multiple actions of estrogens on different cell types have not only intrigued endocrinology researchers but also inspired the development of selective estrogen receptor modulators, or SERMs, that modulate estrogen signaling in a cell type-specific manner. Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology to dissect the mechanisms of estrogen-regulated gene expression in target cells, from in vivo analyses using genetic models deficient in estrogen signaling and from synthetic estrogen receptor ligands with isoform- or pathway-selective activity. These advances, and their implications for clinical use, were discussed by leading researchers from industry and academia during an international symposium held in Berlin, 1-3 March 2006 and are featured in this volume.

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BT - Tissue-Specific Estrogen Action Novel Mechanisms, Novel Ligands, Novel Therapies

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