The Role of ERα and ERβ in the Prostate: Insights from Genetic Models and Isoform-Selective Ligands

Stephen John McPherson, Stuart John Ellem, Vladamir Patchev, Karl-Heinrich Fritzemeier, Gail Petuna Risbridger

    Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

    Abstract

    The multiple actions of estrogens on different cell types have not only intrigued endocrinology researchers but also inspired the development of selective estrogen receptor modulators, or SERMs, that modulate estrogen signaling in a cell type-specific manner. Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology to dissect the mechanisms of estrogen-regulated gene expression in target cells, from in vivo analyses using genetic models deficient in estrogen signaling and from synthetic estrogen receptor ligands with isoform- or pathway-selective activity. These advances, and their implications for clinical use, were discussed by leading researchers from industry and academia during an international symposium held in Berlin, 1-3 March 2006 and are featured in this volume.
    Original languageEnglish
    Title of host publicationTissue-Specific Estrogen Action Novel Mechanisms, Novel Ligands, Novel Therapies
    EditorsK S Korach, T Wintermantel
    Place of PublicationGermany
    PublisherSpringer
    Pages131-148
    Number of pages18
    Edition1st
    ISBN (Print)978-3-540-49547-5
    Publication statusPublished - 2007

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