TY - JOUR
T1 - The role of epigenetics in personalized medicine
T2 - Challenges and opportunities
AU - Rasool, Mahmood
AU - Malik, Arif
AU - Naseer, Muhammad Imran
AU - Manan, Abdul
AU - Ansari, Shakeel Ahmed
AU - Begum, Irshad
AU - Qazi, Mahmood Husain
AU - Pushparaj, Peter Natesan
AU - Abuzenadah, Adel M.
AU - Al-Qahtani, Mohammed Hussein
AU - Kamal, Mohammad Amjad
AU - Gan, Siew Hua
N1 - Funding Information:
The authors would like to thank the facilities provided by the King Abdulaziz University, the University of Lahore and the Universiti Sains Malaysia. Publication fees has been paid by Centre of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, KSA. MR is supported by KACST Strategic Project code: 12-MED3078-03. PNP is funded by KACST Strategic Project Codes: 12-BIO2719-03 and 12-BIO2267-03”. MIN is funded by KACST Strategic Project Codes: 12-BIO3059-03 and APR-34-13.
Publisher Copyright:
© Rasool et al; licensee BioMed Central Ltd.
PY - 2015/1/15
Y1 - 2015/1/15
N2 - Epigenetic alterations are considered to be very influential in both the normal and disease states of an organism. These alterations include methylation, acetylation, phosphorylation, and ubiquitylation of DNA and histone proteins (nucleosomes) as well as chromatin remodeling. Many diseases, such as cancers and neurodegenerative disorders, are often associated with epigenetic alterations. DNA methylation is one important modification that leads to disease. Standard therapies are given to patients; however, few patients respond to these drugs, because of various molecular alterations in their cells, which may be partially due to genetic heterogeneity and epigenetic alterations. To realize the promise of personalized medicine, both genetic and epigenetic diagnostic testing will be required. This review will discuss the advances that have been made as well as the challenges for the future.
AB - Epigenetic alterations are considered to be very influential in both the normal and disease states of an organism. These alterations include methylation, acetylation, phosphorylation, and ubiquitylation of DNA and histone proteins (nucleosomes) as well as chromatin remodeling. Many diseases, such as cancers and neurodegenerative disorders, are often associated with epigenetic alterations. DNA methylation is one important modification that leads to disease. Standard therapies are given to patients; however, few patients respond to these drugs, because of various molecular alterations in their cells, which may be partially due to genetic heterogeneity and epigenetic alterations. To realize the promise of personalized medicine, both genetic and epigenetic diagnostic testing will be required. This review will discuss the advances that have been made as well as the challenges for the future.
UR - https://www.scopus.com/pages/publications/84928339162
U2 - 10.1186/1755-8794-8-S1-S5
DO - 10.1186/1755-8794-8-S1-S5
M3 - Review Article
C2 - 25951941
AN - SCOPUS:84928339162
SN - 1471-2164
VL - 8
JO - BMC Genomics
JF - BMC Genomics
IS - 1
M1 - S5
ER -
SDG 3 Good Health and Well-being