The role of dihydrosphingolipids in disease

Ruth R. Magaye, Feby Savira, Yue Hua, Darren J. Kelly, Christopher Reid, Bernard Flynn, Danny Liew, Bing H. Wang

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph), dihydrosphingosine (dhSph), dihydrosphingosine-1-phosphate (dhS1P) and dihydroceramide (dhCer). Recent advances in research related to sphingolipid biochemistry have shed light on the importance of sphingolipids in terms of cellular signalling in health and disease. However, dihydrosphingolipids have received less attention and research is lacking especially in terms of their molecular mechanisms of action. This is despite studies implicating them in the pathophysiology of disease, for example dhCer in predicting type 2 diabetes in obese individuals, dhS1P in cardiovascular diseases and dhSph in hepato-renal toxicity. This review gives a comprehensive summary of research in the last 10–15 years on the dihydrosphingolipids, 3-ketoSph, dhSph, dhS1P and dhCer, and their relevant roles in different diseases. It also highlights gaps in research that could be of future interest.

Original languageEnglish
Pages (from-to)1107-1134
Number of pages28
JournalCellular and Molecular Life Sciences
Volume76
Issue number6
DOIs
Publication statusPublished - Mar 2019

Keywords

  • 4-HRP fenretinide
  • Adipocyte
  • Aging
  • Airway hypersensitivity
  • Apoptosis
  • Autophagy
  • Cancer
  • Cardiomyopathy
  • Ceramide
  • Ceramide synthase
  • Diabetes
  • Dihydroceramide desaturase 1-Des-1
  • Dihydrosphinganine
  • FB1 toxicity
  • Hypoxia
  • Neurodegenerative
  • Serine palmitoyl transferase
  • Sphingosine kinase
  • Sphingosine-1-phosphate receptors
  • Sphingosine-1-phosphate—S1P

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