The role of chemokine receptors in primary, effector, and memory immune responses

Federica Sallusto, Charles R. Mackay, Antonio Lanzavecchia

Research output: Contribution to journalReview ArticleResearchpeer-review

898 Citations (Scopus)

Abstract

The immune system is composed of single cells, and its function is entirely dependent on the capacity of these cells to traffic, localize within tissues, and interact with each other in a precisely coordinated fashion. There is growing evidence that the large families of chemokines and chemokine receptors provide a flexible code for regulating cell traffic and positioning in both homeostatic and inflammatory conditions. The regulation of chemokine receptor expression during development and following cell activation explains the complex migratory pathways taken by dendritic cells, T and B lymphocytes, providing new insights into the mechanisms that control priming, effector function, and memory responses.

Original languageEnglish
Pages (from-to)593-620
Number of pages28
JournalAnnual Review of Immunology
Volume18
DOIs
Publication statusPublished - 27 Jun 2000
Externally publishedYes

Keywords

  • Chemokine
  • Dendritic cell
  • Immune response
  • Memory T cell
  • Th1
  • Th2

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