The role of CD27 in anti-viral T-cell immunity

Emma J Grant; Simone Nussing; Sneha Sant; E Bridie Clemens; Katherine Kedzierska

doi:10.1016/j.coviro.2016.12.001

The role of CD27 in anti-viral T-cell immunity

Emma J Grant, Simone Nussing, Sneha Sant, E Bridie Clemens, Katherine Kedzierska

Research output: Contribution to journal › Review Article › Research › peer-review

37 Citations (Scopus)

Abstract

CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8⁺ T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.

Original language	English
Pages (from-to)	77-88
Number of pages	12
Journal	Current Opinion in Virology
Volume	22
DOIs	https://doi.org/10.1016/j.coviro.2016.12.001
Publication status	Published - Feb 2017
Externally published	Yes

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10.1016/j.coviro.2016.12.001

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title = "The role of CD27 in anti-viral T-cell immunity",

abstract = "CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.",

author = "Grant, {Emma J} and Simone Nussing and Sneha Sant and Clemens, {E Bridie} and Katherine Kedzierska",

year = "2017",

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language = "English",

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journal = "Current Opinion in Virology",

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T1 - The role of CD27 in anti-viral T-cell immunity

AU - Grant, Emma J

AU - Nussing, Simone

AU - Sant, Sneha

AU - Clemens, E Bridie

AU - Kedzierska, Katherine

PY - 2017/2

Y1 - 2017/2

N2 - CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.

AB - CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.

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U2 - 10.1016/j.coviro.2016.12.001

DO - 10.1016/j.coviro.2016.12.001

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SN - 1879-6257

VL - 22

SP - 77

EP - 88

JO - Current Opinion in Virology

JF - Current Opinion in Virology

ER -

The role of CD27 in anti-viral T-cell immunity

Abstract

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Identification and characterisation of HLA-E restricted influenza A virus-specific CD8+ T cells

Limiting the impact of influenza

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The role of CD27 in anti-viral T-cell immunity

Abstract

Access to Document

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Projects

Identification and characterisation of HLA-E restricted influenza A virus-specific CD8+ T cells

Limiting the impact of influenza

Cite this