The role of CD27 in anti-viral T-cell immunity

Emma J Grant, Simone Nussing, Sneha Sant, E Bridie Clemens, Katherine Kedzierska

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.

Original languageEnglish
Pages (from-to)77-88
Number of pages12
JournalCurrent Opinion in Virology
Volume22
DOIs
Publication statusPublished - Feb 2017
Externally publishedYes

Cite this

Grant, Emma J ; Nussing, Simone ; Sant, Sneha ; Clemens, E Bridie ; Kedzierska, Katherine. / The role of CD27 in anti-viral T-cell immunity. In: Current Opinion in Virology. 2017 ; Vol. 22. pp. 77-88.
@article{2522dc971eb04db7b9f5571a8d3c6448,
title = "The role of CD27 in anti-viral T-cell immunity",
abstract = "CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.",
author = "Grant, {Emma J} and Simone Nussing and Sneha Sant and Clemens, {E Bridie} and Katherine Kedzierska",
year = "2017",
month = "2",
doi = "10.1016/j.coviro.2016.12.001",
language = "English",
volume = "22",
pages = "77--88",
journal = "Current Opinion in Virology",
issn = "1879-6257",
publisher = "Elsevier",

}

The role of CD27 in anti-viral T-cell immunity. / Grant, Emma J; Nussing, Simone; Sant, Sneha; Clemens, E Bridie; Kedzierska, Katherine.

In: Current Opinion in Virology, Vol. 22, 02.2017, p. 77-88.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - The role of CD27 in anti-viral T-cell immunity

AU - Grant, Emma J

AU - Nussing, Simone

AU - Sant, Sneha

AU - Clemens, E Bridie

AU - Kedzierska, Katherine

PY - 2017/2

Y1 - 2017/2

N2 - CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.

AB - CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.

UR - http://www.scopus.com/inward/record.url?scp=85009089861&partnerID=8YFLogxK

U2 - 10.1016/j.coviro.2016.12.001

DO - 10.1016/j.coviro.2016.12.001

M3 - Review Article

VL - 22

SP - 77

EP - 88

JO - Current Opinion in Virology

JF - Current Opinion in Virology

SN - 1879-6257

ER -