Abstract
CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 77-88 |
| Number of pages | 12 |
| Journal | Current Opinion in Virology |
| Volume | 22 |
| DOIs | |
| Publication status | Published - Feb 2017 |
| Externally published | Yes |
Cite this
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The role of CD27 in anti-viral T-cell immunity. / Grant, Emma J; Nussing, Simone; Sant, Sneha; Clemens, E Bridie; Kedzierska, Katherine.
In: Current Opinion in Virology, Vol. 22, 02.2017, p. 77-88.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - The role of CD27 in anti-viral T-cell immunity
AU - Grant, Emma J
AU - Nussing, Simone
AU - Sant, Sneha
AU - Clemens, E Bridie
AU - Kedzierska, Katherine
PY - 2017/2
Y1 - 2017/2
N2 - CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.
AB - CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8+ T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.
UR - http://www.scopus.com/inward/record.url?scp=85009089861&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2016.12.001
DO - 10.1016/j.coviro.2016.12.001
M3 - Review Article
VL - 22
SP - 77
EP - 88
JO - Current Opinion in Virology
JF - Current Opinion in Virology
SN - 1879-6257
ER -