The role of cardiac tissue macrophages in homeostasis and disease

Alexei Ilinykh, Alexander R. Pinto

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

3 Citations (Scopus)

Abstract

Macrophages are principally recognized as an important cell type for removal of tissue debris and as sentinels for tissue damage and foreign antigens. However, macrophages also participate in a diverse range of biological processes including angiogenesis, fibrosis, immune modulation, cell survival, and stem cell mobilization. Cardiac tissue macrophages (cTMs) are a heterogeneous population of phagocytic cells with distinct ontogenetic, phenotypic, and functional characteristics. While our understanding of cTMs has increased substantially over the last 5 years, large gaps in our knowledge regarding the cell biology of cTMs exist, in particular, the development of their unique phenotype and their roles in cardiac homeostasis and tissue stress. This review aims to discuss the current knowledge regarding cTMs and identify key questions that must be addressed to gain a better understanding of the role of cTMs in tissue development, homeostasis, and disease.

Original languageEnglish
Title of host publicationThe Immunology of Cardiovascular Homeostasis and Pathology
EditorsSusanne Sattler, Teresa Kennedy-Lydon
PublisherSpringer
Chapter6
Pages105-118
Number of pages14
Volume1003
ISBN (Electronic)9783319576138
ISBN (Print)9783319576114
DOIs
Publication statusPublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1003
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Cardiac homeostasis
  • Cardiac ischemia
  • Cardiac macrophages
  • Cardiac tissue macrophages
  • cTMs
  • Heart immune cells
  • Macrophages

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