TY - CHAP
T1 - The role of cardiac tissue macrophages in homeostasis and disease
AU - Ilinykh, Alexei
AU - Pinto, Alexander R.
PY - 2017
Y1 - 2017
N2 - Macrophages are principally recognized as an important cell type for removal of tissue debris and as sentinels for tissue damage and foreign antigens. However, macrophages also participate in a diverse range of biological processes including angiogenesis, fibrosis, immune modulation, cell survival, and stem cell mobilization. Cardiac tissue macrophages (cTMs) are a heterogeneous population of phagocytic cells with distinct ontogenetic, phenotypic, and functional characteristics. While our understanding of cTMs has increased substantially over the last 5 years, large gaps in our knowledge regarding the cell biology of cTMs exist, in particular, the development of their unique phenotype and their roles in cardiac homeostasis and tissue stress. This review aims to discuss the current knowledge regarding cTMs and identify key questions that must be addressed to gain a better understanding of the role of cTMs in tissue development, homeostasis, and disease.
AB - Macrophages are principally recognized as an important cell type for removal of tissue debris and as sentinels for tissue damage and foreign antigens. However, macrophages also participate in a diverse range of biological processes including angiogenesis, fibrosis, immune modulation, cell survival, and stem cell mobilization. Cardiac tissue macrophages (cTMs) are a heterogeneous population of phagocytic cells with distinct ontogenetic, phenotypic, and functional characteristics. While our understanding of cTMs has increased substantially over the last 5 years, large gaps in our knowledge regarding the cell biology of cTMs exist, in particular, the development of their unique phenotype and their roles in cardiac homeostasis and tissue stress. This review aims to discuss the current knowledge regarding cTMs and identify key questions that must be addressed to gain a better understanding of the role of cTMs in tissue development, homeostasis, and disease.
KW - Cardiac homeostasis
KW - Cardiac ischemia
KW - Cardiac macrophages
KW - Cardiac tissue macrophages
KW - cTMs
KW - Heart immune cells
KW - Macrophages
UR - http://www.scopus.com/inward/record.url?scp=85021674054&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-57613-8_6
DO - 10.1007/978-3-319-57613-8_6
M3 - Chapter (Book)
C2 - 28667556
AN - SCOPUS:85021674054
SN - 9783319576114
VL - 1003
T3 - Advances in Experimental Medicine and Biology
SP - 105
EP - 118
BT - The Immunology of Cardiovascular Homeostasis and Pathology
A2 - Sattler, Susanne
A2 - Kennedy-Lydon, Teresa
PB - Springer
ER -