The Role of Antigen Presentation and Innate Immunity During Immune Induction by Particulate Antigens

M. R. Neeland, M. J. de Veer, J. P.Y. Scheerlinck

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

Abstract

While nonliving vaccines are considered safer than live attenuated vaccines, they often require the addition of immune stimulants known as adjuvants, which enhance adaptive and memory immune responses generated to the vaccine. Adjuvants can also influence the type of immune response generated, enhancing the selectivity and specificity of the vaccine. The ability of adjuvants to enhance vaccine immune outcomes has several benefits in a clinical setting, including reducing antigen dosage and decreasing the number of vaccinations required to successfully immunize a patient.

Original languageEnglish
Title of host publicationMicro- and Nanotechnology in Vaccine Development
EditorsMariusz Skwarczynski, Istvan Toth
Place of PublicationOxford UK
PublisherElsevier
Pages83-98
Number of pages16
ISBN (Electronic)9780323400299
ISBN (Print)9780323399814
DOIs
Publication statusPublished - 2017

Keywords

  • Adaptive immunity
  • Nanoparticle vaccine delivery system
  • Particulate antigen
  • Vaccine adjuvants

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