The Role of Antigen Presentation and Innate Immunity During Immune Induction by Particulate Antigens

M. R. Neeland; M. J. de Veer; J. P.Y. Scheerlinck

doi:10.1016/B978-0-323-39981-4.00005-1

The Role of Antigen Presentation and Innate Immunity During Immune Induction by Particulate Antigens

M. R. Neeland, M. J. de Veer, J. P.Y. Scheerlinck

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

1 Citation (Scopus)

Abstract

While nonliving vaccines are considered safer than live attenuated vaccines, they often require the addition of immune stimulants known as adjuvants, which enhance adaptive and memory immune responses generated to the vaccine. Adjuvants can also influence the type of immune response generated, enhancing the selectivity and specificity of the vaccine. The ability of adjuvants to enhance vaccine immune outcomes has several benefits in a clinical setting, including reducing antigen dosage and decreasing the number of vaccinations required to successfully immunize a patient.

Original language	English
Title of host publication	Micro- and Nanotechnology in Vaccine Development
Editors	Mariusz Skwarczynski, Istvan Toth
Place of Publication	Oxford UK
Publisher	Elsevier
Pages	83-98
Number of pages	16
ISBN (Electronic)	9780323400299
ISBN (Print)	9780323399814
DOIs	https://doi.org/10.1016/B978-0-323-39981-4.00005-1
Publication status	Published - 2017

Keywords

Adaptive immunity
Nanoparticle vaccine delivery system
Particulate antigen
Vaccine adjuvants

Access to Document

10.1016/B978-0-323-39981-4.00005-1

Link to publication in Scopus

Cite this

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abstract = "While nonliving vaccines are considered safer than live attenuated vaccines, they often require the addition of immune stimulants known as adjuvants, which enhance adaptive and memory immune responses generated to the vaccine. Adjuvants can also influence the type of immune response generated, enhancing the selectivity and specificity of the vaccine. The ability of adjuvants to enhance vaccine immune outcomes has several benefits in a clinical setting, including reducing antigen dosage and decreasing the number of vaccinations required to successfully immunize a patient.",

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The Role of Antigen Presentation and Innate Immunity During Immune Induction by Particulate Antigens. / Neeland, M. R.; de Veer, M. J.; Scheerlinck, J. P.Y.

Micro- and Nanotechnology in Vaccine Development. ed. / Mariusz Skwarczynski; Istvan Toth. Oxford UK : Elsevier, 2017. p. 83-98.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

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