The role of androgen therapy

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

The concept of a female androgen insufficiency syndrome, although not new, remains somewhat controversial. Androgens are quantitatively the predominant sex steroid in women, circulating in the micromolar and nanomolar concentration range, compared with picomolar levels of oestrogens. The most significant biologically active androgen is testosterone (T), which circulates bound tightly to sex-horprone-binding globulin (SHBG) and loosely to albumin. It is generally held that the non-SHBG-bound fraction is the bioavailable moiety. Hence, clinically useful T measurements require data on total concentrations as well as SHBG level. Testosterone insufficiency occurs in a number of circumstances, including hypopituitarism, premature ovarian failure, adrenal failure, exogenous corticosteroid use and oral oestrogen therapy (causing elevation of SHBG and suppression of gonadotrophins). Clinical symptoms of androgen insufficiency include loss of libido, diminished well-being, fatigue and blunted motivation and have been reported to respond well to T replacement, generally without significant side-effects.

Original languageEnglish
Pages (from-to)165-175
Number of pages11
JournalBest Practice and Research in Clinical Endocrinology and Metabolism
Volume17
Issue number1
DOIs
Publication statusPublished - 2003

Keywords

  • Dehydroepiandrosterone sulphate
  • Free testosterone
  • Hypopituitarism
  • Libido
  • Premature ovarian failure
  • Sex hormone binding globulin
  • Testosterone
  • Well-being.

Cite this

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title = "The role of androgen therapy",
abstract = "The concept of a female androgen insufficiency syndrome, although not new, remains somewhat controversial. Androgens are quantitatively the predominant sex steroid in women, circulating in the micromolar and nanomolar concentration range, compared with picomolar levels of oestrogens. The most significant biologically active androgen is testosterone (T), which circulates bound tightly to sex-horprone-binding globulin (SHBG) and loosely to albumin. It is generally held that the non-SHBG-bound fraction is the bioavailable moiety. Hence, clinically useful T measurements require data on total concentrations as well as SHBG level. Testosterone insufficiency occurs in a number of circumstances, including hypopituitarism, premature ovarian failure, adrenal failure, exogenous corticosteroid use and oral oestrogen therapy (causing elevation of SHBG and suppression of gonadotrophins). Clinical symptoms of androgen insufficiency include loss of libido, diminished well-being, fatigue and blunted motivation and have been reported to respond well to T replacement, generally without significant side-effects.",
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The role of androgen therapy. / Davis, Susan R.; Burger, Henry G.

In: Best Practice and Research in Clinical Endocrinology and Metabolism, Vol. 17, No. 1, 2003, p. 165-175.

Research output: Contribution to journalReview ArticleResearchpeer-review

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AU - Davis, Susan R.

AU - Burger, Henry G.

PY - 2003

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KW - Sex hormone binding globulin

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