The Role of AGE‐RAGE Signalling as a Modulator of Gut Permeability in Diabetes

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

There is increasing evidence for the role of intestinal permeability as a contributing factor in the pathogenesis of diabetes; however, the molecular mechanisms are poorly understood. Advanced glycation endproducts, of both exogenous and endogenous origin, have been shown to play a role in diabetes pathophysiology, in part by their ligation to the receptor for advanced glycation endproducts (RAGE), leading to a proinflammatory signalling cascade. RAGE signalling has been demonstrated to play a role in the development of intestinal inflammation and permeability in Crohn’s disease and ulcerative colitis. In this review, we explore the role of AGE‐ RAGE signalling and intestinal permeability and explore whether activation of RAGE on the intestinal epithelium may be a downstream event contributing to the pathogenesis of diabetes complications.

Original languageEnglish
Article number1766
Number of pages13
JournalInternational Journal of Molecular Sciences
Volume23
Issue number3
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Advanced glycation endproducts
  • Diabetes
  • Intestinal permeability
  • Receptor for advanced glycation endproducts

Cite this