TY - JOUR
T1 - The role of ADHD associated genes in neurodevelopment
AU - Dark, Callum
AU - Homman-Ludiye, Jihane
AU - Bryson-Richardson, Robert J.
PY - 2018/6/15
Y1 - 2018/6/15
N2 - Attention deficit hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder of childhood. It is primarily characterised by high levels of activity, inattention, and impulsivity, and has strong negative impacts on academic functioning. Children with ADHD show a reduction in volume, and hypoactivity, in a range of brain regions. The underlying mechanisms behind these phenotypes are unknown, however, variants in several genes with known roles in neurodevelopment are associated with ADHD. In this review we discuss how these ADHD associated genes contribute to neurodevelopment, and how variants in these genes could give rise to the neurological phenotypes seen in ADHD.
AB - Attention deficit hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder of childhood. It is primarily characterised by high levels of activity, inattention, and impulsivity, and has strong negative impacts on academic functioning. Children with ADHD show a reduction in volume, and hypoactivity, in a range of brain regions. The underlying mechanisms behind these phenotypes are unknown, however, variants in several genes with known roles in neurodevelopment are associated with ADHD. In this review we discuss how these ADHD associated genes contribute to neurodevelopment, and how variants in these genes could give rise to the neurological phenotypes seen in ADHD.
KW - ADHD
KW - Neurodevelopment
KW - Psychiatric disorder
KW - Synaptogenesis
UR - http://www.scopus.com/inward/record.url?scp=85046819850&partnerID=8YFLogxK
U2 - 10.1016/j.ydbio.2018.03.023
DO - 10.1016/j.ydbio.2018.03.023
M3 - Review Article
C2 - 29608877
AN - SCOPUS:85046819850
VL - 438
SP - 69
EP - 83
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 2
ER -