The rise and fall of genomic methylation in cancer

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25 Citations (Scopus)


Changes in genomic methylation and its significance in carcinogenesis is in the spotlight once again, though the focus is not on the usual suspects, DNA hypermethylation and tumour suppressor gene (TSG) silencing. Several recent reports provide compelling evidence of the relevance of genomic hypomethylation in cancer. These findings provide the best evidence so for that links the loss of DNA methylation and chromosomal instability with cancer development. This review article discusses these recent findings and reflects on the antithetical association between DNA methylation and carcinogenesis and the re-examination of studies performed almost two decades ago.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
Issue number2
Publication statusPublished - 1 Jan 2004


  • Cancer
  • Epigenetics
  • Histones
  • Methylation
  • Methyltransferases
  • Mice knockouts

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