The rise and fall of genomic methylation in cancer

Research output: Contribution to journalShort SurveyOtherpeer-review

Abstract

Changes in genomic methylation and its significance in carcinogenesis is in the spotlight once again, though the focus is not on the usual suspects, DNA hypermethylation and tumour suppressor gene (TSG) silencing. Several recent reports provide compelling evidence of the relevance of genomic hypomethylation in cancer. These findings provide the best evidence so for that links the loss of DNA methylation and chromosomal instability with cancer development. This review article discusses these recent findings and reflects on the antithetical association between DNA methylation and carcinogenesis and the re-examination of studies performed almost two decades ago.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalLeukemia
Volume18
Issue number2
DOIs
Publication statusPublished - 1 Jan 2004

Keywords

  • Cancer
  • Epigenetics
  • Histones
  • Methylation
  • Methyltransferases
  • Mice knockouts

Cite this

@article{7e70c2e24e8a4da5bc1ca451015f4954,
title = "The rise and fall of genomic methylation in cancer",
abstract = "Changes in genomic methylation and its significance in carcinogenesis is in the spotlight once again, though the focus is not on the usual suspects, DNA hypermethylation and tumour suppressor gene (TSG) silencing. Several recent reports provide compelling evidence of the relevance of genomic hypomethylation in cancer. These findings provide the best evidence so for that links the loss of DNA methylation and chromosomal instability with cancer development. This review article discusses these recent findings and reflects on the antithetical association between DNA methylation and carcinogenesis and the re-examination of studies performed almost two decades ago.",
keywords = "Cancer, Epigenetics, Histones, Methylation, Methyltransferases, Mice knockouts",
author = "Assam El-Osta",
year = "2004",
month = "1",
day = "1",
doi = "10.1038/sj.leu.2403218",
language = "English",
volume = "18",
pages = "233--237",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Macmillan Publishers",
number = "2",

}

The rise and fall of genomic methylation in cancer. / El-Osta, Assam.

In: Leukemia, Vol. 18, No. 2, 01.01.2004, p. 233-237.

Research output: Contribution to journalShort SurveyOtherpeer-review

TY - JOUR

T1 - The rise and fall of genomic methylation in cancer

AU - El-Osta, Assam

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Changes in genomic methylation and its significance in carcinogenesis is in the spotlight once again, though the focus is not on the usual suspects, DNA hypermethylation and tumour suppressor gene (TSG) silencing. Several recent reports provide compelling evidence of the relevance of genomic hypomethylation in cancer. These findings provide the best evidence so for that links the loss of DNA methylation and chromosomal instability with cancer development. This review article discusses these recent findings and reflects on the antithetical association between DNA methylation and carcinogenesis and the re-examination of studies performed almost two decades ago.

AB - Changes in genomic methylation and its significance in carcinogenesis is in the spotlight once again, though the focus is not on the usual suspects, DNA hypermethylation and tumour suppressor gene (TSG) silencing. Several recent reports provide compelling evidence of the relevance of genomic hypomethylation in cancer. These findings provide the best evidence so for that links the loss of DNA methylation and chromosomal instability with cancer development. This review article discusses these recent findings and reflects on the antithetical association between DNA methylation and carcinogenesis and the re-examination of studies performed almost two decades ago.

KW - Cancer

KW - Epigenetics

KW - Histones

KW - Methylation

KW - Methyltransferases

KW - Mice knockouts

UR - http://www.scopus.com/inward/record.url?scp=1242329901&partnerID=8YFLogxK

U2 - 10.1038/sj.leu.2403218

DO - 10.1038/sj.leu.2403218

M3 - Short Survey

VL - 18

SP - 233

EP - 237

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 2

ER -