The resistance to host antimicrobial peptides in infections caused by daptomycin-resistant staphylococcus aureus

Md Saruar Bhuiyan, Jhih-Hang Jiang, Xenia Kostoulias, Ravali Theegala, Graham J. Lieschke, Anton Y. Peleg

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5 Citations (Scopus)


Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible S. aureus paired isolates using a zebrafish infection model. We showed that the control of DAP-R S. aureus infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R S. aureus and provide crucial insights into the adaptive evolution of this troublesome pathogen.

Original languageEnglish
Article number96
Number of pages6
Issue number2
Publication statusPublished - Feb 2021


  • Antimicrobial peptides
  • Daptomycin
  • Persistent infection
  • S. aureus

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