The resistance to host antimicrobial peptides in infections caused by daptomycin-resistant staphylococcus aureus

Md Saruar Bhuiyan; Jhih-Hang Jiang; Xenia Kostoulias; Ravali Theegala; Graham J. Lieschke; Anton Y. Peleg

doi:10.3390/antibiotics10020096

The resistance to host antimicrobial peptides in infections caused by daptomycin-resistant staphylococcus aureus

Md Saruar Bhuiyan, Jhih-Hang Jiang, Xenia Kostoulias, Ravali Theegala, Graham J. Lieschke, Anton Y. Peleg

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible S. aureus paired isolates using a zebrafish infection model. We showed that the control of DAP-R S. aureus infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R S. aureus and provide crucial insights into the adaptive evolution of this troublesome pathogen.

Original language	English
Article number	96
Number of pages	6
Journal	Antibiotics
Volume	10
Issue number	2
DOIs	https://doi.org/10.3390/antibiotics10020096
Publication status	Published - Feb 2021

Keywords

Antimicrobial peptides
Daptomycin
Persistent infection
S. aureus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/antibiotics10020096Licence: CC BY

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abstract = "Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible S. aureus paired isolates using a zebrafish infection model. We showed that the control of DAP-R S. aureus infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R S. aureus and provide crucial insights into the adaptive evolution of this troublesome pathogen.",

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AU - Theegala, Ravali

AU - Lieschke, Graham J.

AU - Peleg, Anton Y.

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AB - Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible S. aureus paired isolates using a zebrafish infection model. We showed that the control of DAP-R S. aureus infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R S. aureus and provide crucial insights into the adaptive evolution of this troublesome pathogen.

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The resistance to host antimicrobial peptides in infections caused by daptomycin-resistant staphylococcus aureus

Abstract

Keywords

UN SDGs

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Antibiotic Resistance and Host Immune Evasion in Staphylococcus aureus

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The resistance to host antimicrobial peptides in infections caused by daptomycin-resistant staphylococcus aureus

Abstract

Keywords

UN SDGs

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Antibiotic Resistance and Host Immune Evasion in Staphylococcus aureus

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