The renin-angiotensin-aldosterone system and its therapeutic targets

Katrina M. Mirabito Colafella, Dominique Bovée, Jan Danser

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the regulation of blood pressure and body fluid homeostasis and is a mainstay for the treatment of cardiovascular and renal diseases. Angiotensin II and aldosterone are the two most powerful biologically active products of the RAAS, inducing all of the classical actions of the RAAS including vasoconstriction, sodium retention, tissue remodeling and pro-inflammatory and pro-fibrotic effects. In recent years, new components of the RAAS have been discovered beyond the classical pathway that have led to the identification of depressor or so-called protective RAAS pathways and the development of novel therapies targeting this system. Moreover, dual inhibitors which block the RAAS and other systems involved in the regulation of blood pressure or targeting upstream of angiotensin II by selectively deleting liver-derived angiotensinogen, the precursor to all angiotensins, may provide superior treatment for cardiovascular and renal diseases and revolutionize RAAS-targeting therapy.
Original languageEnglish
Article number107680
Number of pages7
JournalExperimental Eye Research
Volume186
DOIs
Publication statusPublished - Sep 2019

Keywords

  • Mineralocorticoid receptor antagonist
  • Angiotensin-converting enzyme inhibitor
  • AT1 receptor blocker
  • renin inhibitor
  • angiotensinogen siRNA
  • AT2 receptor agonist
  • neprilysin inhibitor
  • Mas receptor agonist
  • ACE2

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