The health-care industry requires large expenditure on research and development (R D), with many projects undergoing long development cycles, usually with uncertain outcomes. Extant research has mainly concentrated on the health-care industry in the United States, where R D costs are expensed as incurred. Previous Australian research has found mixed results in relation to R D expenditure and changes in share price. This study investigates whether R D expenditure reported in the health-care industry since the introduction of IAS 38 is significantly associated with share price. Results of the study show that expensed R D is value-relevant, while a comparison of the pre and post-IAS 38 periods (including pre-global financial crisis (GFC) and GFC periods) shows a statistically significant improvement in the explanatory power of the regression model post-IAS 38, suggesting that R D expenditure reported under the new standard IAS 38 is more useful for decision-making by investors compared with reporting under AASB 1011.