The Relationship of Collagen Structural and Compositional Heterogeneity to Tissue Mechanical Properties: A Chemical Perspective

Junjie Chen, Taeyong Ahn, Isabel D. Colón-Bernal, Jinhee Kim, Mark M. Banaszak Holl

Research output: Contribution to journalReview ArticleOtherpeer-review

15 Citations (Scopus)


Collagen is the primary protein component in mammalian connective tissues. Over the last 20 years, evidence has mounted that collagen matrices exhibit substantial heterogeneity in their hierarchical structures and that this heterogeneity plays important roles in both structure and function. Herein, an overview of studies addressing the nanoscale compositional and structural heterogeneity is provided and connected to work exploring the mechanical implications for a number of tissues.

Original languageEnglish
Pages (from-to)10665-10671
Number of pages7
JournalACS Nano
Issue number11
Publication statusPublished - 28 Nov 2017
Externally publishedYes

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