The relationship between the placental serotonin pathway and fetal growth restriction

Suveena Ranzil, David W. Walker, Anthony J. Borg, Euan M. Wallace, Peter R. Ebeling, Padma Murthi

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Fetal growth restriction (FGR)is a complex disorder of human pregnancy that leads to poor health outcomes in offspring. These range from immediate risks such as perinatal morbidity and stillbirths, to long-term complications including severe neurodevelopmental problems. Despite its relatively high global prevalence, the aetiology of FGR and its complications is not currently well understood. We now know that serotonin (5-HT)is synthesised in the placenta and is crucial for early fetal forebrain development in mice. However, the contribution of a disrupted placental 5-HT synthetic pathway to the pathophysiology of placental insufficiency in FGR and its significant fetal neurodevelopmental complications are unclear.

Original languageEnglish
Pages (from-to)80-87
Number of pages8
JournalBiochimie
Volume161
DOIs
Publication statusPublished - 1 Jun 2019

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