Abstract
Fetal growth restriction (FGR)is a complex disorder of human pregnancy that leads to poor health outcomes in offspring. These range from immediate risks such as perinatal morbidity and stillbirths, to long-term complications including severe neurodevelopmental problems. Despite its relatively high global prevalence, the aetiology of FGR and its complications is not currently well understood. We now know that serotonin (5-HT)is synthesised in the placenta and is crucial for early fetal forebrain development in mice. However, the contribution of a disrupted placental 5-HT synthetic pathway to the pathophysiology of placental insufficiency in FGR and its significant fetal neurodevelopmental complications are unclear.
Original language | English |
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Pages (from-to) | 80-87 |
Number of pages | 8 |
Journal | Biochimie |
Volume | 161 |
DOIs | |
Publication status | Published - 1 Jun 2019 |