Abstract
Fetal growth restriction (FGR)is a complex disorder of human pregnancy that leads to poor health outcomes in offspring. These range from immediate risks such as perinatal morbidity and stillbirths, to long-term complications including severe neurodevelopmental problems. Despite its relatively high global prevalence, the aetiology of FGR and its complications is not currently well understood. We now know that serotonin (5-HT)is synthesised in the placenta and is crucial for early fetal forebrain development in mice. However, the contribution of a disrupted placental 5-HT synthetic pathway to the pathophysiology of placental insufficiency in FGR and its significant fetal neurodevelopmental complications are unclear.
| Original language | English |
|---|---|
| Pages (from-to) | 80-87 |
| Number of pages | 8 |
| Journal | Biochimie |
| Volume | 161 |
| DOIs | |
| Publication status | Published - 1 Jun 2019 |
Cite this
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The relationship between the placental serotonin pathway and fetal growth restriction. / Ranzil, Suveena; Walker, David W.; Borg, Anthony J.; Wallace, Euan M.; Ebeling, Peter R.; Murthi, Padma.
In: Biochimie, Vol. 161, 01.06.2019, p. 80-87.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - The relationship between the placental serotonin pathway and fetal growth restriction
AU - Ranzil, Suveena
AU - Walker, David W.
AU - Borg, Anthony J.
AU - Wallace, Euan M.
AU - Ebeling, Peter R.
AU - Murthi, Padma
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Fetal growth restriction (FGR)is a complex disorder of human pregnancy that leads to poor health outcomes in offspring. These range from immediate risks such as perinatal morbidity and stillbirths, to long-term complications including severe neurodevelopmental problems. Despite its relatively high global prevalence, the aetiology of FGR and its complications is not currently well understood. We now know that serotonin (5-HT)is synthesised in the placenta and is crucial for early fetal forebrain development in mice. However, the contribution of a disrupted placental 5-HT synthetic pathway to the pathophysiology of placental insufficiency in FGR and its significant fetal neurodevelopmental complications are unclear.
AB - Fetal growth restriction (FGR)is a complex disorder of human pregnancy that leads to poor health outcomes in offspring. These range from immediate risks such as perinatal morbidity and stillbirths, to long-term complications including severe neurodevelopmental problems. Despite its relatively high global prevalence, the aetiology of FGR and its complications is not currently well understood. We now know that serotonin (5-HT)is synthesised in the placenta and is crucial for early fetal forebrain development in mice. However, the contribution of a disrupted placental 5-HT synthetic pathway to the pathophysiology of placental insufficiency in FGR and its significant fetal neurodevelopmental complications are unclear.
UR - http://www.scopus.com/inward/record.url?scp=85059857099&partnerID=8YFLogxK
U2 - 10.1016/j.biochi.2018.12.016
DO - 10.1016/j.biochi.2018.12.016
M3 - Review Article
VL - 161
SP - 80
EP - 87
JO - Biochimie
JF - Biochimie
SN - 0300-9084
ER -