The relationship between the placental serotonin pathway and fetal growth restriction

Suveena Ranzil; David W. Walker; Anthony J. Borg; Euan M. Wallace; Peter R. Ebeling; Padma Murthi

doi:10.1016/j.biochi.2018.12.016

The relationship between the placental serotonin pathway and fetal growth restriction

Suveena Ranzil, David W. Walker, Anthony J. Borg, Euan M. Wallace, Peter R. Ebeling, Padma Murthi

Research output: Contribution to journal › Review Article › Research › peer-review

3 Citations (Scopus)

Abstract

Fetal growth restriction (FGR)is a complex disorder of human pregnancy that leads to poor health outcomes in offspring. These range from immediate risks such as perinatal morbidity and stillbirths, to long-term complications including severe neurodevelopmental problems. Despite its relatively high global prevalence, the aetiology of FGR and its complications is not currently well understood. We now know that serotonin (5-HT)is synthesised in the placenta and is crucial for early fetal forebrain development in mice. However, the contribution of a disrupted placental 5-HT synthetic pathway to the pathophysiology of placental insufficiency in FGR and its significant fetal neurodevelopmental complications are unclear.

Original language	English
Pages (from-to)	80-87
Number of pages	8
Journal	Biochimie
Volume	161
DOIs	https://doi.org/10.1016/j.biochi.2018.12.016
Publication status	Published - 1 Jun 2019

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10.1016/j.biochi.2018.12.016

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Cite this

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title = "The relationship between the placental serotonin pathway and fetal growth restriction",

abstract = "Fetal growth restriction (FGR)is a complex disorder of human pregnancy that leads to poor health outcomes in offspring. These range from immediate risks such as perinatal morbidity and stillbirths, to long-term complications including severe neurodevelopmental problems. Despite its relatively high global prevalence, the aetiology of FGR and its complications is not currently well understood. We now know that serotonin (5-HT)is synthesised in the placenta and is crucial for early fetal forebrain development in mice. However, the contribution of a disrupted placental 5-HT synthetic pathway to the pathophysiology of placental insufficiency in FGR and its significant fetal neurodevelopmental complications are unclear.",

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AU - Ranzil, Suveena

AU - Walker, David W.

AU - Borg, Anthony J.

AU - Wallace, Euan M.

AU - Ebeling, Peter R.

AU - Murthi, Padma

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N2 - Fetal growth restriction (FGR)is a complex disorder of human pregnancy that leads to poor health outcomes in offspring. These range from immediate risks such as perinatal morbidity and stillbirths, to long-term complications including severe neurodevelopmental problems. Despite its relatively high global prevalence, the aetiology of FGR and its complications is not currently well understood. We now know that serotonin (5-HT)is synthesised in the placenta and is crucial for early fetal forebrain development in mice. However, the contribution of a disrupted placental 5-HT synthetic pathway to the pathophysiology of placental insufficiency in FGR and its significant fetal neurodevelopmental complications are unclear.

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