TY - JOUR
T1 - The relationship between severity of liver steatosis and metabolic parameters in a sample of Iranian adults
AU - Tutunchi, Helda
AU - Saghafi-Asl, Maryam
AU - Asghari-Jafarabadi, Mohammad
AU - Ostadrahimi, Alireza
N1 - Funding Information:
This research was funded by the Nutrition Research Center of Tabriz University of Medical Sciences and Iran National Science Foundation (INSF), Grant Number: 694. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2020 The Author(s).
PY - 2020/4/16
Y1 - 2020/4/16
N2 - Objectives: This study aimed to examine the relationship between severity of liver steatosis and metabolic parameters in a sample of Iranian adults. In this cross-sectional study, a total of 95 subjects aged > 20 years newly diagnosed with NAFLD were recruited. NAFLD was diagnosed using ultrasonography by a single expert radiologist in a fasting state. Results: The mean age of the patients was 49.27 (SD 9.7) years, with 53.68% males and 46.32% females. Most patients had grade I NAFLD (72.63%), 25.26% were grade II, and 2.11% were grade III on ultrasonography. With increasing severity of liver steatosis, there were statistically significant increases in mean body mass index (P = 0.001), serum triglycerides (P = 0.026), alanine aminotransferase (P < 0.001), aspartate aminotransferase (P < 0.001), and fasting blood sugar (P = 0.041), and there was a statistically significant decrease in mean serum high-density lipoprotein cholesterol (P = 0.011). However, no association was found between severity of liver steatosis and serum total cholesterol (P = 0.271), low-density lipoprotein cholesterol (P = 0.341), and alkaline phosphatase (P = 0.234). In conclusion, the severity of ultrasonographic liver steatosis was significantly associated with abnormal metabolic parameters.
AB - Objectives: This study aimed to examine the relationship between severity of liver steatosis and metabolic parameters in a sample of Iranian adults. In this cross-sectional study, a total of 95 subjects aged > 20 years newly diagnosed with NAFLD were recruited. NAFLD was diagnosed using ultrasonography by a single expert radiologist in a fasting state. Results: The mean age of the patients was 49.27 (SD 9.7) years, with 53.68% males and 46.32% females. Most patients had grade I NAFLD (72.63%), 25.26% were grade II, and 2.11% were grade III on ultrasonography. With increasing severity of liver steatosis, there were statistically significant increases in mean body mass index (P = 0.001), serum triglycerides (P = 0.026), alanine aminotransferase (P < 0.001), aspartate aminotransferase (P < 0.001), and fasting blood sugar (P = 0.041), and there was a statistically significant decrease in mean serum high-density lipoprotein cholesterol (P = 0.011). However, no association was found between severity of liver steatosis and serum total cholesterol (P = 0.271), low-density lipoprotein cholesterol (P = 0.341), and alkaline phosphatase (P = 0.234). In conclusion, the severity of ultrasonographic liver steatosis was significantly associated with abnormal metabolic parameters.
KW - Body mass index
KW - Metabolic parameters
KW - NAFLD
KW - Obesity
KW - Ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=85083520563&partnerID=8YFLogxK
U2 - 10.1186/s13104-020-05059-5
DO - 10.1186/s13104-020-05059-5
M3 - Article
C2 - 32299490
AN - SCOPUS:85083520563
SN - 1756-0500
VL - 13
JO - BMC Research Notes
JF - BMC Research Notes
IS - 1
M1 - 218
ER -
