The relationship between severity of liver steatosis and metabolic parameters in a sample of Iranian adults

Helda Tutunchi, Maryam Saghafi-Asl, Mohammad Asghari-Jafarabadi, Alireza Ostadrahimi

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

Objectives: This study aimed to examine the relationship between severity of liver steatosis and metabolic parameters in a sample of Iranian adults. In this cross-sectional study, a total of 95 subjects aged > 20 years newly diagnosed with NAFLD were recruited. NAFLD was diagnosed using ultrasonography by a single expert radiologist in a fasting state. Results: The mean age of the patients was 49.27 (SD 9.7) years, with 53.68% males and 46.32% females. Most patients had grade I NAFLD (72.63%), 25.26% were grade II, and 2.11% were grade III on ultrasonography. With increasing severity of liver steatosis, there were statistically significant increases in mean body mass index (P = 0.001), serum triglycerides (P = 0.026), alanine aminotransferase (P < 0.001), aspartate aminotransferase (P < 0.001), and fasting blood sugar (P = 0.041), and there was a statistically significant decrease in mean serum high-density lipoprotein cholesterol (P = 0.011). However, no association was found between severity of liver steatosis and serum total cholesterol (P = 0.271), low-density lipoprotein cholesterol (P = 0.341), and alkaline phosphatase (P = 0.234). In conclusion, the severity of ultrasonographic liver steatosis was significantly associated with abnormal metabolic parameters.

Original languageEnglish
Article number218
Number of pages5
JournalBMC Research Notes
Volume13
Issue number1
DOIs
Publication statusPublished - 16 Apr 2020
Externally publishedYes

Keywords

  • Body mass index
  • Metabolic parameters
  • NAFLD
  • Obesity
  • Ultrasonography

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