The relationship between cortisol and verbal memory in the early stages of Huntington's disease

Christopher Shirbin, Phyllis Chua, Andrew J Churchyard, Anthony J Hannan, Georgina Johanna Lowndes, Julie C Stout

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8 Citations (Scopus)


Hypothalamic pituitary adrenal (HPA) axis hyperactivity has been linked to learning and memory difficulties in a range of neurodegenerative and neuropsychiatric conditions. In Huntington?s disease (HD), both declines in learning and memory and HPA axis dysfunction are present early in the disease. However, the relationship between specific learning and memory deficits and HPA axis functioning in HD has not been examined. The aim of this study was to investigate cortisol levels in relation to verbal learning and memory in pre-diagnosed (pre-HD) participants and patients at the early stages of diagnosed HD (early-HD). Cortisol concentration was assayed in saliva samples from 57 participants (17 early-HD, 20 pre-HD, and 20 controls) at four time-points across a 24-h period
Original languageEnglish
Pages (from-to)891 - 902
Number of pages12
JournalJournal of Neurology
Issue number3
Publication statusPublished - 2013

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