The relationship between cognitive and neuroimaging outcomes in children treated for acute lymphoblastic leukemia with chemotherapy only: A systematic review

Simone Hearps, Marc Seal, Vicki Anderson, Maria McCarthy, Madeleine Connellan, Peter Downie, Cinzia de Luca

Research output: Contribution to journalReview ArticleResearchpeer-review

31 Citations (Scopus)


Cognitive late-effects have been identified in patients treated with chemotherapy-only protocols for childhood acute lymphoblastic leukemia (ALL), yet the underlying neuropathology is not well understood. This review synthesized recent findings from eight articles investigating the relationship between neurocognitive and neuroimaging outcomes for patients treated for ALL with chemotherapy-only protocols. Reported cognitive domains, imaging methods, and neuroanatomy examined were variable. Despite this, 62.5% (n = 5) of the reviewed studies found a significant relationship between cognitive and imaging outcomes. Greater understanding of the effects of treatment on neuroanatomy and cognitive outcomes is critical for proactively managing ALL cognitive late-effects. Research directions are suggested.

Original languageEnglish
Pages (from-to)225-233
Number of pages9
JournalPediatric Blood and Cancer
Issue number2
Publication statusPublished - 1 Feb 2017


  • acute lymphoblastic leukemia
  • cognition
  • neuroimaging
  • pediatric

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