The relationship between Activin A and anti-angiogenic factors in the development of pre-eclampsia

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Abstract

Anti-angiogenic factors such as sFlt/sEng contribute to the pathology seen in preeclampsia. Activin A, which is released by the placenta following exposure to oxidative stress and elevated in preeclampsia, may interact with sFlt/sEng during the disease process. Using placental explant cultures, we determined that transcription of sFLT1, ENG and INHBA was upregulated following exposure to oxidative stress or IL-6. Explants treated with Activin A did not increase transcription of sFLT1, ENG. Conversely, treatment of placental explants with sFlt/sEng did not increase transcription of INHBA. These data may suggest that Activin A and sFlt/sEng contribute to preeclampsia via separate pathways. ? 2013 International Society for the Study of Hypertension in Pregnancy.
Original languageEnglish
Pages (from-to)3 - 6
Number of pages4
JournalPregnancy Hypertension
Volume4
Issue number1
DOIs
Publication statusPublished - 2014

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