The relationship between α2-adrenoceptor selectivity and anticonvulsant effect in a series of clonidine-like drugs

Jenny Papanicolaou, Roger J. Summers, Frank J.E. Vajda, William J. Louis

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41 Citations (Scopus)

Abstract

Clonidine and the 4 clonidine-like drugs: 44-549, lofexidine, guanfacine, and CP-14,304-18, had anticonvulsant activity against pentylenetetrazole-induced convulsions in rats. The magnitude and dose range over which anticonvulsant effects were observed was related to the selectivity of the compounds for α2 and α1 adrenoceptors. Selective α2 adrenoceptor agonists may form a new group of anticonvulsants.

Original languageEnglish
Pages (from-to)393-397
Number of pages5
JournalBrain Research
Volume241
Issue number2
DOIs
Publication statusPublished - 10 Jun 1982

Keywords

  • 44-549
  • adrenergic α receptors
  • anticonvulsant activity
  • clonidine
  • CP-14,304-18
  • guanfacine
  • lofexidine
  • pentylenetetrazole

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