Clonidine and the 4 clonidine-like drugs: 44-549, lofexidine, guanfacine, and CP-14,304-18, had anticonvulsant activity against pentylenetetrazole-induced convulsions in rats. The magnitude and dose range over which anticonvulsant effects were observed was related to the selectivity of the compounds for α2 and α1 adrenoceptors. Selective α2 adrenoceptor agonists may form a new group of anticonvulsants.
- adrenergic α receptors
- anticonvulsant activity