The relationship between α2-adrenoceptor selectivity and anticonvulsant effect in a series of clonidine-like drugs

Jenny Papanicolaou; Roger J. Summers; Frank J.E. Vajda; William J. Louis

doi:10.1016/0006-8993(82)91086-1

The relationship between α₂-adrenoceptor selectivity and anticonvulsant effect in a series of clonidine-like drugs

Jenny Papanicolaou, Roger J. Summers, Frank J.E. Vajda, William J. Louis

Research output: Contribution to journal › Article › Research › peer-review

42 Citations (Scopus)

Abstract

Clonidine and the 4 clonidine-like drugs: 44-549, lofexidine, guanfacine, and CP-14,304-18, had anticonvulsant activity against pentylenetetrazole-induced convulsions in rats. The magnitude and dose range over which anticonvulsant effects were observed was related to the selectivity of the compounds for α₂ and α₁ adrenoceptors. Selective α₂ adrenoceptor agonists may form a new group of anticonvulsants.

Original language	English
Pages (from-to)	393-397
Number of pages	5
Journal	Brain Research
Volume	241
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(82)91086-1
Publication status	Published - 10 Jun 1982

Keywords

44-549
adrenergic α receptors
anticonvulsant activity
clonidine
CP-14,304-18
guanfacine
lofexidine
pentylenetetrazole

Access to Document

10.1016/0006-8993(82)91086-1

Cite this

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title = "The relationship between α2-adrenoceptor selectivity and anticonvulsant effect in a series of clonidine-like drugs",

abstract = "Clonidine and the 4 clonidine-like drugs: 44-549, lofexidine, guanfacine, and CP-14,304-18, had anticonvulsant activity against pentylenetetrazole-induced convulsions in rats. The magnitude and dose range over which anticonvulsant effects were observed was related to the selectivity of the compounds for α2 and α1 adrenoceptors. Selective α2 adrenoceptor agonists may form a new group of anticonvulsants.",

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AU - Louis, William J.

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