The regulatory landscape of neurite development in Caenorhabditis elegans

Rasoul Godini, Hossein Fallahi, Roger Pocock

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Neuronal communication requires precise connectivity of neurite projections (axons and dendrites). Developing neurites express cell-surface receptors that interpret extracellular cues to enable correct guidance toward, and connection with, target cells. Spatiotemporal regulation of neurite guidance molecule expression by transcription factors (TFs) is critical for nervous system development and function. Here, we review how neurite development is regulated by TFs in the Caenorhabditis elegans nervous system. By collecting publicly available transcriptome and ChIP-sequencing data, we reveal gene expression dynamics during neurite development, providing insight into transcriptional mechanisms governing construction of the nervous system architecture.

Original languageEnglish
Article number974208
Number of pages22
JournalFrontiers in Molecular Neuroscience
Volume15
DOIs
Publication statusPublished - 25 Aug 2022

Keywords

  • Caenorhabditis elegans
  • gene regulatory landscape
  • neurite development
  • neuronal guidance
  • transcription factors

Cite this