Projects per year
Abstract
Neuronal communication requires precise connectivity of neurite projections (axons and dendrites). Developing neurites express cell-surface receptors that interpret extracellular cues to enable correct guidance toward, and connection with, target cells. Spatiotemporal regulation of neurite guidance molecule expression by transcription factors (TFs) is critical for nervous system development and function. Here, we review how neurite development is regulated by TFs in the Caenorhabditis elegans nervous system. By collecting publicly available transcriptome and ChIP-sequencing data, we reveal gene expression dynamics during neurite development, providing insight into transcriptional mechanisms governing construction of the nervous system architecture.
Original language | English |
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Article number | 974208 |
Number of pages | 22 |
Journal | Frontiers in Molecular Neuroscience |
Volume | 15 |
DOIs | |
Publication status | Published - 25 Aug 2022 |
Keywords
- Caenorhabditis elegans
- gene regulatory landscape
- neurite development
- neuronal guidance
- transcription factors
Projects
- 4 Finished
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Transcriptional control of germ cell development
Pocock, R. & Gopal, S.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/22
Project: Research
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Investigating a novel factor impacting stem cell development
Pocock, R. & Gopal, S.
1/01/20 → 31/12/23
Project: Research
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Decoding mechanisms of brain-intestinal communication
Pocock, R. (Primary Chief Investigator (PCI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/18 → 31/12/22
Project: Research