The regulation of fibrosis in airway remodeling in asthma

Simon G Royce, Victor Cheng, Chrishan Samuel, Mimi L K Tang

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

Fibrosis is one of the key pathological features of airway remodeling in asthma. In the normal airway the amount of collagen and other extracellular matrix components is kept in equilibrium by regulation of synthesis and degradation. In asthma this homeostasis is disrupted due to genetic and environmental factors. In the airways of patients with the disease there is increased extracellular matrix deposition, particularly in the reticular basement membrane region, lamina propria and submucosa. Fibrosis is important as it can occur early in the pathogenesis of asthma, be associated with severity and resistant to therapy. In this review we will discuss current knowledge of relaxin and other key regulators of fibrosis in the airway including TGFbeta, Smad2/3 and matrix metalloproteinases. As fibrosis is not directly targeted or effectively treated by current asthma drugs including corticosteroids, characterization of airway fibrosis and how it is regulated will be essential for the development of novel therapies for asthma.
Original languageEnglish
Pages (from-to)167 - 175
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume351
Issue number2
DOIs
Publication statusPublished - 2012

Cite this

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abstract = "Fibrosis is one of the key pathological features of airway remodeling in asthma. In the normal airway the amount of collagen and other extracellular matrix components is kept in equilibrium by regulation of synthesis and degradation. In asthma this homeostasis is disrupted due to genetic and environmental factors. In the airways of patients with the disease there is increased extracellular matrix deposition, particularly in the reticular basement membrane region, lamina propria and submucosa. Fibrosis is important as it can occur early in the pathogenesis of asthma, be associated with severity and resistant to therapy. In this review we will discuss current knowledge of relaxin and other key regulators of fibrosis in the airway including TGFbeta, Smad2/3 and matrix metalloproteinases. As fibrosis is not directly targeted or effectively treated by current asthma drugs including corticosteroids, characterization of airway fibrosis and how it is regulated will be essential for the development of novel therapies for asthma.",
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The regulation of fibrosis in airway remodeling in asthma. / Royce, Simon G; Cheng, Victor; Samuel, Chrishan; Tang, Mimi L K.

In: Molecular and Cellular Endocrinology, Vol. 351, No. 2, 2012, p. 167 - 175.

Research output: Contribution to journalArticleResearchpeer-review

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