The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

Steve Gerondakis; Raelene Grumont; Ian Rourke; Mathis Grossmann

doi:10.1016/S0952-7915(98)80175-1

The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

Steve Gerondakis, Raelene Grumont, Ian Rourke, Mathis Grossmann

Research output: Contribution to journal › Review Article › Research › peer-review

181 Citations (Scopus)

Abstract

The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-κB (NF-κB) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-κB family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.

Original language	English
Pages (from-to)	353-359
Number of pages	7
Journal	Current Opinion in Immunology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/S0952-7915(98)80175-1
Publication status	Published - 1 Jan 1998
Externally published	Yes

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10.1016/S0952-7915(98)80175-1

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title = "The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation",

abstract = "The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-κB (NF-κB) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-κB family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.",

author = "Steve Gerondakis and Raelene Grumont and Ian Rourke and Mathis Grossmann",

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AU - Rourke, Ian

AU - Grossmann, Mathis

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Y1 - 1998/1/1

N2 - The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-κB (NF-κB) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-κB family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.

AB - The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-κB (NF-κB) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-κB family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.

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U2 - 10.1016/S0952-7915(98)80175-1

DO - 10.1016/S0952-7915(98)80175-1

M3 - Review Article

C2 - 9638373

AN - SCOPUS:0031833431

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JO - Current Opinion in Immunology

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The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

Abstract

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