The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

Steve Gerondakis, Raelene Grumont, Ian Rourke, Mathis Grossmann

Research output: Contribution to journalReview ArticleResearchpeer-review

179 Citations (Scopus)

Abstract

The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-κB (NF-κB) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-κB family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.

Original languageEnglish
Pages (from-to)353-359
Number of pages7
JournalCurrent Opinion in Immunology
Volume10
Issue number3
DOIs
Publication statusPublished - 1 Jan 1998
Externally publishedYes

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