The regulation and role of carbohydrate response element-binding protein in metabolic homeostasis and disease

T. Jois, M. W. Sleeman

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Abstract

The transcription factor carbohydrate response element-binding protein (ChREBP) is a member of the basic helix-loop-helix leucine zipper transcription factor family. Under high-glucose conditions, it has a role in regulating the expression of key genes involved in various pathways, including glycolysis, gluconeogenesis and lipogenesis. It does this by forming a tetrameric complex made up of two ChREBP/Mlx heterodimers, which enables it to bind to the carbohydrate response element (ChoRE) in the promoter region of its target genes to regulate transcription. Because ChREBP plays a key role in glucose signalling and metabolism, and aberrations in glucose homeostasis are often present in metabolic diseases, this transcription factor presents itself as an enticing target with respect to further understanding metabolic disease mechanisms and potentially uncovering new therapeutic targets.

Original languageEnglish
Article numbere12473
Number of pages11
JournalJournal of Neuroendocrinology
Volume29
Issue number10
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • carbohydrate response element-binding protein
  • glucose homeostasis
  • hepatic steatosis
  • insulin resistance

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