The regioselective iodination of quinolines, quinolones, pyridones, pyridines and uracil

Uttam Dutta, Arghya Deb, David Lupton, Debabrata Maiti

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A radical based direct C-H iodination protocol for quinolines, quinolones, pyridones, pyridines, and uracil has been developed. The iodination occurs in a C3 selective manner for quinolines and quinolones. Pyridones and pyridines undergo C3 and C5 iodination, while dimethyl uracil undergoes C5 iodination. Scope of the method was demonstrated through the rapid synthesis of both electron rich as well as electron poor heteroaromatic iodides. The protocol was found to be scalable and general, while a mechanism has been proposed
Original languageEnglish
Pages (from-to)17744-17747
Number of pages4
JournalChemical Communications
Issue number100
Publication statusPublished - 2015

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