Abstract
In the retinotectal system, positional information has long been postulated to take the form of molecular gradients within both the retina and the tectum. Recent reports have implicated Mek4, a member of the Eph (also named class V) family of tyrosine kinase receptors (RTKs), and two ligands, RAGS and ELF-1, in this process. Here, we report the cloning and distribution pattern of QEK5, another member of the Eph family of RTKs, isolated from a quail cDNA library. During retinal differentiation, QEK5 transcripts accumulate in a ventral to dorsal gradient within the retinal neuroepithelium, where its expression becomes restricted to the ganglion and bipolar cell layers. Within the tectum, QEK5 transcripts are detectable in a posterior to anterior gradient in the ventricular layer and newly formed superficial layers. The pattern of QEK5 expression in the retina and tectum is distinct from that of Mek4, suggesting that complex patterns of Eph RTKs and their ligands may play a role in cell-cell interactions involved in retinotectal projections and differentiation of the central nervous system.
| Original language | English |
|---|---|
| Pages (from-to) | 708-716 |
| Number of pages | 9 |
| Journal | Developmental Biology |
| Volume | 172 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1995 |
| Externally published | Yes |
Cite this
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The receptor tyrosine kinase QEK5 mRNA is expressed in a gradient within the neural retina and the tectum. / Kenny, Daryn; Bronner-Fraser, Marianne; Marcelle, Christophe.
In: Developmental Biology, Vol. 172, No. 2, 1995, p. 708-716.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - The receptor tyrosine kinase QEK5 mRNA is expressed in a gradient within the neural retina and the tectum
AU - Kenny, Daryn
AU - Bronner-Fraser, Marianne
AU - Marcelle, Christophe
PY - 1995
Y1 - 1995
N2 - In the retinotectal system, positional information has long been postulated to take the form of molecular gradients within both the retina and the tectum. Recent reports have implicated Mek4, a member of the Eph (also named class V) family of tyrosine kinase receptors (RTKs), and two ligands, RAGS and ELF-1, in this process. Here, we report the cloning and distribution pattern of QEK5, another member of the Eph family of RTKs, isolated from a quail cDNA library. During retinal differentiation, QEK5 transcripts accumulate in a ventral to dorsal gradient within the retinal neuroepithelium, where its expression becomes restricted to the ganglion and bipolar cell layers. Within the tectum, QEK5 transcripts are detectable in a posterior to anterior gradient in the ventricular layer and newly formed superficial layers. The pattern of QEK5 expression in the retina and tectum is distinct from that of Mek4, suggesting that complex patterns of Eph RTKs and their ligands may play a role in cell-cell interactions involved in retinotectal projections and differentiation of the central nervous system.
AB - In the retinotectal system, positional information has long been postulated to take the form of molecular gradients within both the retina and the tectum. Recent reports have implicated Mek4, a member of the Eph (also named class V) family of tyrosine kinase receptors (RTKs), and two ligands, RAGS and ELF-1, in this process. Here, we report the cloning and distribution pattern of QEK5, another member of the Eph family of RTKs, isolated from a quail cDNA library. During retinal differentiation, QEK5 transcripts accumulate in a ventral to dorsal gradient within the retinal neuroepithelium, where its expression becomes restricted to the ganglion and bipolar cell layers. Within the tectum, QEK5 transcripts are detectable in a posterior to anterior gradient in the ventricular layer and newly formed superficial layers. The pattern of QEK5 expression in the retina and tectum is distinct from that of Mek4, suggesting that complex patterns of Eph RTKs and their ligands may play a role in cell-cell interactions involved in retinotectal projections and differentiation of the central nervous system.
UR - http://www.scopus.com/inward/record.url?scp=0029562537&partnerID=8YFLogxK
U2 - 10.1006/dbio.1995.8083
DO - 10.1006/dbio.1995.8083
M3 - Article
VL - 172
SP - 708
EP - 716
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 2
ER -