The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling

Kim Gia Lieu, Aaron Brice, Linda Wiltzer, Bevan Hirst, David Andrew Jans, Danielle Blondel, Gregory William Moseley

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40 Citations (Scopus)

Abstract

Immune evasion by rabies virus depends on targeting of the signal transducers and activator of transcription 1 (STAT1) and STAT2 proteins by the viral interferon antagonist P protein, but targeting of other STAT proteins has not been investigated. Here, we find that P protein associates with activated STAT3 and inhibits STAT3 nuclear accumulation and Gp130-dependent signaling. This is the first report of STAT3 targeting by the interferon antagonist of a virus other than a paramyxovirus, indicating that STAT3 antagonism is important to a range of human-pathogenic viruses.
Original languageEnglish
Pages (from-to)8261 - 8265
Number of pages5
JournalJournal of Virology
Volume87
Issue number14
DOIs
Publication statusPublished - 2013

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