The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling

Kim Gia Lieu, Aaron Brice, Linda Wiltzer, Bevan Hirst, David Andrew Jans, Danielle Blondel, Gregory William Moseley

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Abstract

Immune evasion by rabies virus depends on targeting of the signal transducers and activator of transcription 1 (STAT1) and STAT2 proteins by the viral interferon antagonist P protein, but targeting of other STAT proteins has not been investigated. Here, we find that P protein associates with activated STAT3 and inhibits STAT3 nuclear accumulation and Gp130-dependent signaling. This is the first report of STAT3 targeting by the interferon antagonist of a virus other than a paramyxovirus, indicating that STAT3 antagonism is important to a range of human-pathogenic viruses.
Original languageEnglish
Pages (from-to)8261 - 8265
Number of pages5
JournalJournal of Virology
Volume87
Issue number14
DOIs
Publication statusPublished - 2013

Cite this

Lieu, Kim Gia ; Brice, Aaron ; Wiltzer, Linda ; Hirst, Bevan ; Jans, David Andrew ; Blondel, Danielle ; Moseley, Gregory William. / The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling. In: Journal of Virology. 2013 ; Vol. 87, No. 14. pp. 8261 - 8265.
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The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling. / Lieu, Kim Gia; Brice, Aaron; Wiltzer, Linda; Hirst, Bevan; Jans, David Andrew; Blondel, Danielle; Moseley, Gregory William.

In: Journal of Virology, Vol. 87, No. 14, 2013, p. 8261 - 8265.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Brice, Aaron

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AU - Blondel, Danielle

AU - Moseley, Gregory William

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AB - Immune evasion by rabies virus depends on targeting of the signal transducers and activator of transcription 1 (STAT1) and STAT2 proteins by the viral interferon antagonist P protein, but targeting of other STAT proteins has not been investigated. Here, we find that P protein associates with activated STAT3 and inhibits STAT3 nuclear accumulation and Gp130-dependent signaling. This is the first report of STAT3 targeting by the interferon antagonist of a virus other than a paramyxovirus, indicating that STAT3 antagonism is important to a range of human-pathogenic viruses.

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