The pseudokinases SgK269 and SgK223

A novel oncogenic alliance in human cancer

Rachelle L. O'Rourke, Roger J. Daly

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Sugen kinases (SgK)269 (also known as PEAK1), and SgK223, an orthologue of rat pragmin and mouse NACK, are human pseudokinases that are implicated in the progression of several cancers. Both are scaffolding proteins that recruit distinct repertoires of signalling proteins and regulate a variety of biological endpoints including cell migration and invasion. To date, SgK269 and SgK223 have been largely studied as separate signalling entities. However, recent work has demonstrated that SgK269 and SgK223 undergo homo- and heterotypic association that determines signal output and biological response. Further characterization of the mechanism of action of these two pseudokinases will provide novel insights into how they promote cancer progression and may reveal novel therapeutic strategies. Here we review their structure, mechanism and function and roles they play in cancer pathogenesis.

Original languageEnglish
Pages (from-to)524-528
Number of pages5
JournalCell Adhesion and Migration
Volume12
Issue number6
DOIs
Publication statusPublished - 2018

Keywords

  • NACK
  • pragmin
  • protein kinase
  • tyrosine phosphorylation

Cite this

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abstract = "Sugen kinases (SgK)269 (also known as PEAK1), and SgK223, an orthologue of rat pragmin and mouse NACK, are human pseudokinases that are implicated in the progression of several cancers. Both are scaffolding proteins that recruit distinct repertoires of signalling proteins and regulate a variety of biological endpoints including cell migration and invasion. To date, SgK269 and SgK223 have been largely studied as separate signalling entities. However, recent work has demonstrated that SgK269 and SgK223 undergo homo- and heterotypic association that determines signal output and biological response. Further characterization of the mechanism of action of these two pseudokinases will provide novel insights into how they promote cancer progression and may reveal novel therapeutic strategies. Here we review their structure, mechanism and function and roles they play in cancer pathogenesis.",
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The pseudokinases SgK269 and SgK223 : A novel oncogenic alliance in human cancer. / O'Rourke, Rachelle L.; Daly, Roger J.

In: Cell Adhesion and Migration, Vol. 12, No. 6, 2018, p. 524-528.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - The pseudokinases SgK269 and SgK223

T2 - A novel oncogenic alliance in human cancer

AU - O'Rourke, Rachelle L.

AU - Daly, Roger J.

PY - 2018

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AB - Sugen kinases (SgK)269 (also known as PEAK1), and SgK223, an orthologue of rat pragmin and mouse NACK, are human pseudokinases that are implicated in the progression of several cancers. Both are scaffolding proteins that recruit distinct repertoires of signalling proteins and regulate a variety of biological endpoints including cell migration and invasion. To date, SgK269 and SgK223 have been largely studied as separate signalling entities. However, recent work has demonstrated that SgK269 and SgK223 undergo homo- and heterotypic association that determines signal output and biological response. Further characterization of the mechanism of action of these two pseudokinases will provide novel insights into how they promote cancer progression and may reveal novel therapeutic strategies. Here we review their structure, mechanism and function and roles they play in cancer pathogenesis.

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