TY - JOUR
T1 - The pseudokinases SgK269 and SgK223
T2 - A novel oncogenic alliance in human cancer
AU - O'Rourke, Rachelle L.
AU - Daly, Roger J.
PY - 2018
Y1 - 2018
N2 - Sugen kinases (SgK)269 (also known as PEAK1), and SgK223, an orthologue of rat pragmin and mouse NACK, are human pseudokinases that are implicated in the progression of several cancers. Both are scaffolding proteins that recruit distinct repertoires of signalling proteins and regulate a variety of biological endpoints including cell migration and invasion. To date, SgK269 and SgK223 have been largely studied as separate signalling entities. However, recent work has demonstrated that SgK269 and SgK223 undergo homo- and heterotypic association that determines signal output and biological response. Further characterization of the mechanism of action of these two pseudokinases will provide novel insights into how they promote cancer progression and may reveal novel therapeutic strategies. Here we review their structure, mechanism and function and roles they play in cancer pathogenesis.
AB - Sugen kinases (SgK)269 (also known as PEAK1), and SgK223, an orthologue of rat pragmin and mouse NACK, are human pseudokinases that are implicated in the progression of several cancers. Both are scaffolding proteins that recruit distinct repertoires of signalling proteins and regulate a variety of biological endpoints including cell migration and invasion. To date, SgK269 and SgK223 have been largely studied as separate signalling entities. However, recent work has demonstrated that SgK269 and SgK223 undergo homo- and heterotypic association that determines signal output and biological response. Further characterization of the mechanism of action of these two pseudokinases will provide novel insights into how they promote cancer progression and may reveal novel therapeutic strategies. Here we review their structure, mechanism and function and roles they play in cancer pathogenesis.
KW - NACK
KW - pragmin
KW - protein kinase
KW - tyrosine phosphorylation
UR - http://www.scopus.com/inward/record.url?scp=85038617113&partnerID=8YFLogxK
U2 - 10.1080/19336918.2017.1394570
DO - 10.1080/19336918.2017.1394570
M3 - Article
AN - SCOPUS:85038617113
VL - 12
SP - 524
EP - 528
JO - Cell Adhesion and Migration
JF - Cell Adhesion and Migration
SN - 1933-6918
IS - 6
ER -