The protein import receptor of mitochondria

Trevor Lithgow, Benjamin S. Glick, Gottfried Schatz

Research output: Contribution to journalArticleResearchpeer-review

139 Citations (Scopus)

Abstract

Protein import into the mitochondria of Saccharomyces cerevisiae depends on two receptor subcomplexes composed of integral outer-membrane proteins. One subcomplex is the MAS37-MAS70 heterodimer, which preferentially recognizes the mature regions of precursor proteins associated with ATP-dependent cytosolic chaperones. The other subcomplex contains the acidic proteins MAS20 and MAS22, which recognize the positively charged targeting sequences of a wide variety of mitochondrial precursors. We propose that the two subcomplexes can act together as a single, multifunctional receptor that binds simultaneously to different regions of a precursor molecule.

Original languageEnglish
Pages (from-to)98-101
Number of pages4
JournalTrends in Biochemical Sciences
Volume20
Issue number3
DOIs
Publication statusPublished - 1 Jan 1995
Externally publishedYes

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