Abstract
Protein import into the mitochondria of Saccharomyces cerevisiae depends on two receptor subcomplexes composed of integral outer-membrane proteins. One subcomplex is the MAS37-MAS70 heterodimer, which preferentially recognizes the mature regions of precursor proteins associated with ATP-dependent cytosolic chaperones. The other subcomplex contains the acidic proteins MAS20 and MAS22, which recognize the positively charged targeting sequences of a wide variety of mitochondrial precursors. We propose that the two subcomplexes can act together as a single, multifunctional receptor that binds simultaneously to different regions of a precursor molecule.
Original language | English |
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Pages (from-to) | 98-101 |
Number of pages | 4 |
Journal | Trends in Biochemical Sciences |
Volume | 20 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jan 1995 |
Externally published | Yes |