The protein encoded by the MFT1 gene is a targeting factor for mitochondrial precursor proteins, and not a core ribosomal protein

Traude Beilharz, Travis Beddoe, Karina Landl, Peter Cartwright, Trevor Lithgow

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)


Yeast cells harboring mft1 mutations are compromised in mitochondrial protein targeting, and Mft1p has previously been identified as a ribosomal protein. However, two genes, PLC2 and YML062C, are present in the MFT1 locus, and we show that mft1 mutant cells are compromised in the function of the cytosolic protein encoded by YML062C. The ribosomal protein (YS3a) is actually encoded by the tightly linked PLC2 gene, and does not play a role in targeting proteins to the mitochondria.

Original languageEnglish
Pages (from-to)220-224
Number of pages5
JournalFEBS Letters
Issue number2
Publication statusPublished - 28 Apr 1997
Externally publishedYes


  • Mitochondria
  • Protein targeting
  • Ribosomal protein

Cite this