The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function

Priya S.R. Naidu, Marck Norret, Nicole M. Smith, Sarah A. Dunlop, Nicolas L. Taylor, Melinda Fitzgerald, K. Swaminathan Iyer

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona.

Original languageEnglish
Pages (from-to)12926-12933
Number of pages8
JournalLangmuir
Volume33
Issue number45
DOIs
Publication statusPublished - 14 Nov 2017
Externally publishedYes

Cite this