The promise and peril of chemical probes

Cheryl H. Arrowsmith, James E. Audia, Christopher Austin, Jonathan Baell, Jonathan Bennett, Julian Blagg, Chas Bountra, Paul E. Brennan, Peter J. Brown, Mark E. Bunnage, Carolyn Buser-Doepner, Robert M. Campbell, Adrian J. Carter, Philip Cohen, Robert A. Copeland, Ben Cravatt, Jayme L. Dahlin, Dashyant Dhanak, Aled M. Edwards, Stephen V. Frye

Research output: Contribution to journalComment / DebateResearchpeer-review

316 Citations (Scopus)

Abstract

Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

Original languageEnglish
Pages (from-to)536-541
Number of pages6
JournalNature Chemical Biology
Volume11
Issue number8
DOIs
Publication statusPublished - 21 Jul 2015

Cite this

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., ... Frye, S. V. (2015). The promise and peril of chemical probes. Nature Chemical Biology, 11(8), 536-541. https://doi.org/10.1038/nchembio.1867
Arrowsmith, Cheryl H. ; Audia, James E. ; Austin, Christopher ; Baell, Jonathan ; Bennett, Jonathan ; Blagg, Julian ; Bountra, Chas ; Brennan, Paul E. ; Brown, Peter J. ; Bunnage, Mark E. ; Buser-Doepner, Carolyn ; Campbell, Robert M. ; Carter, Adrian J. ; Cohen, Philip ; Copeland, Robert A. ; Cravatt, Ben ; Dahlin, Jayme L. ; Dhanak, Dashyant ; Edwards, Aled M. ; Frye, Stephen V. / The promise and peril of chemical probes. In: Nature Chemical Biology. 2015 ; Vol. 11, No. 8. pp. 536-541.
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Arrowsmith, CH, Audia, JE, Austin, C, Baell, J, Bennett, J, Blagg, J, Bountra, C, Brennan, PE, Brown, PJ, Bunnage, ME, Buser-Doepner, C, Campbell, RM, Carter, AJ, Cohen, P, Copeland, RA, Cravatt, B, Dahlin, JL, Dhanak, D, Edwards, AM & Frye, SV 2015, 'The promise and peril of chemical probes', Nature Chemical Biology, vol. 11, no. 8, pp. 536-541. https://doi.org/10.1038/nchembio.1867

The promise and peril of chemical probes. / Arrowsmith, Cheryl H.; Audia, James E.; Austin, Christopher; Baell, Jonathan; Bennett, Jonathan; Blagg, Julian; Bountra, Chas; Brennan, Paul E.; Brown, Peter J.; Bunnage, Mark E.; Buser-Doepner, Carolyn; Campbell, Robert M.; Carter, Adrian J.; Cohen, Philip; Copeland, Robert A.; Cravatt, Ben; Dahlin, Jayme L.; Dhanak, Dashyant; Edwards, Aled M.; Frye, Stephen V.

In: Nature Chemical Biology, Vol. 11, No. 8, 21.07.2015, p. 536-541.

Research output: Contribution to journalComment / DebateResearchpeer-review

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AU - Audia, James E.

AU - Austin, Christopher

AU - Baell, Jonathan

AU - Bennett, Jonathan

AU - Blagg, Julian

AU - Bountra, Chas

AU - Brennan, Paul E.

AU - Brown, Peter J.

AU - Bunnage, Mark E.

AU - Buser-Doepner, Carolyn

AU - Campbell, Robert M.

AU - Carter, Adrian J.

AU - Cohen, Philip

AU - Copeland, Robert A.

AU - Cravatt, Ben

AU - Dahlin, Jayme L.

AU - Dhanak, Dashyant

AU - Edwards, Aled M.

AU - Frye, Stephen V.

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Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J et al. The promise and peril of chemical probes. Nature Chemical Biology. 2015 Jul 21;11(8):536-541. https://doi.org/10.1038/nchembio.1867