The promise and peril of chemical probes

Cheryl H. Arrowsmith, James E. Audia, Christopher Austin, Jonathan Baell, Jonathan Bennett, Julian Blagg, Chas Bountra, Paul E. Brennan, Peter J. Brown, Mark E. Bunnage, Carolyn Buser-Doepner, Robert M. Campbell, Adrian J. Carter, Philip Cohen, Robert A. Copeland, Ben Cravatt, Jayme L. Dahlin, Dashyant Dhanak, Aled M. Edwards, Stephen V. Frye

Research output: Contribution to journalComment / DebateResearchpeer-review

393 Citations (Scopus)


Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

Original languageEnglish
Pages (from-to)536-541
Number of pages6
JournalNature Chemical Biology
Issue number8
Publication statusPublished - 21 Jul 2015

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