The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease

Kate Henderson, Hugh Harrington Reid, Natalie Borg, Sophie Elizabeth Broughton, Trevor Huyton, Robert P Anderson, James McCluskey, Jamie Rossjohn

Research output: Contribution to journal › Article › Other

15 Citations (Scopus)

Abstract

The major histocompatibility complex (MHC) class II molecules HLA-DQ2 and HLA-DQ8 are key risk factors in coeliac disease, as they bind deamidated gluten peptides that are subsequently recognized by CD4+ T cells. Here, the production and crystallization of both HLA-DQ2 and HLA-DQ8 in complex with the deamidated gliadin peptides DQ2 alpha-I (PQPELPYPQ) and DQ8 alpha-I (EGSFQPSQE), respectively, are reported.
Original languageEnglish
Pages (from-to)1021 - 1025
Number of pages5
JournalActa Crystallographica. Section F: Structural Biology Communications
Volume63
Issue number12
Publication statusPublished - 2007

Cite this

Henderson, Kate ; Reid, Hugh Harrington ; Borg, Natalie ; Broughton, Sophie Elizabeth ; Huyton, Trevor ; Anderson, Robert P ; McCluskey, James ; Rossjohn, Jamie. / The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease. In: Acta Crystallographica. Section F: Structural Biology Communications. 2007 ; Vol. 63, No. 12. pp. 1021 - 1025.
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title = "The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease",
abstract = "The major histocompatibility complex (MHC) class II molecules HLA-DQ2 and HLA-DQ8 are key risk factors in coeliac disease, as they bind deamidated gluten peptides that are subsequently recognized by CD4+ T cells. Here, the production and crystallization of both HLA-DQ2 and HLA-DQ8 in complex with the deamidated gliadin peptides DQ2 alpha-I (PQPELPYPQ) and DQ8 alpha-I (EGSFQPSQE), respectively, are reported.",
author = "Kate Henderson and Reid, {Hugh Harrington} and Natalie Borg and Broughton, {Sophie Elizabeth} and Trevor Huyton and Anderson, {Robert P} and James McCluskey and Jamie Rossjohn",
year = "2007",
language = "English",
volume = "63",
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Henderson, K, Reid, HH, Borg, N, Broughton, SE, Huyton, T, Anderson, RP, McCluskey, J & Rossjohn, J 2007, 'The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease', Acta Crystallographica. Section F: Structural Biology Communications, vol. 63, no. 12, pp. 1021 - 1025.

The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease. / Henderson, Kate; Reid, Hugh Harrington; Borg, Natalie; Broughton, Sophie Elizabeth; Huyton, Trevor; Anderson, Robert P; McCluskey, James; Rossjohn, Jamie.

In: Acta Crystallographica. Section F: Structural Biology Communications, Vol. 63, No. 12, 2007, p. 1021 - 1025.

Research output: Contribution to journal › Article › Other

TY - JOUR

T1 - The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease

AU - Henderson, Kate

AU - Reid, Hugh Harrington

AU - Borg, Natalie

AU - Broughton, Sophie Elizabeth

AU - Huyton, Trevor

AU - Anderson, Robert P

AU - McCluskey, James

AU - Rossjohn, Jamie

PY - 2007

Y1 - 2007

N2 - The major histocompatibility complex (MHC) class II molecules HLA-DQ2 and HLA-DQ8 are key risk factors in coeliac disease, as they bind deamidated gluten peptides that are subsequently recognized by CD4+ T cells. Here, the production and crystallization of both HLA-DQ2 and HLA-DQ8 in complex with the deamidated gliadin peptides DQ2 alpha-I (PQPELPYPQ) and DQ8 alpha-I (EGSFQPSQE), respectively, are reported.

AB - The major histocompatibility complex (MHC) class II molecules HLA-DQ2 and HLA-DQ8 are key risk factors in coeliac disease, as they bind deamidated gluten peptides that are subsequently recognized by CD4+ T cells. Here, the production and crystallization of both HLA-DQ2 and HLA-DQ8 in complex with the deamidated gliadin peptides DQ2 alpha-I (PQPELPYPQ) and DQ8 alpha-I (EGSFQPSQE), respectively, are reported.

UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18084083

M3 - Article

VL - 63

SP - 1021

EP - 1025

JO - Acta Crystallographica. Section F: Structural Biology Communications

JF - Acta Crystallographica. Section F: Structural Biology Communications

SN - 2053-230X

IS - 12

ER -

Henderson K, Reid HH, Borg N, Broughton SE, Huyton T, Anderson RP et al. The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease. Acta Crystallographica. Section F: Structural Biology Communications. 2007;63(12):1021 - 1025.

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