The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease

Kate Henderson, Hugh Harrington Reid, Natalie Borg, Sophie Elizabeth Broughton, Trevor Huyton, Robert P Anderson, James McCluskey, Jamie Rossjohn

Research output: Contribution to journalArticleOther

15 Citations (Scopus)

Abstract

The major histocompatibility complex (MHC) class II molecules HLA-DQ2 and HLA-DQ8 are key risk factors in coeliac disease, as they bind deamidated gluten peptides that are subsequently recognized by CD4+ T cells. Here, the production and crystallization of both HLA-DQ2 and HLA-DQ8 in complex with the deamidated gliadin peptides DQ2 alpha-I (PQPELPYPQ) and DQ8 alpha-I (EGSFQPSQE), respectively, are reported.
Original languageEnglish
Pages (from-to)1021 - 1025
Number of pages5
JournalActa Crystallographica Section F: Structural Biology Communications
Volume63
Issue number12
Publication statusPublished - 2007

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