The pro-apoptotic mechanisms of melatonin in cancer

Yiing Jye Yap, Khuen Yen Ng, Rhun Yian Koh, Soi Moi Chye

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1 Citation (Scopus)


Cancer is a leading cause of morbidity and mortality worldwide. Various therapies including chemotherapy, radiation therapy, surgery and hormone therapy have been used in the past decades to treat cancers. However, most treatments are associated with unwanted side effects; therefore a better anticancer approach that has less severe side effects and better efficacy is needed. Melatonin is an endogenous indolamine hormone that is mainly produced and secreted by pineal gland. It has oncostatic properties and induces apoptosis in cancer cells. This review describes the pro-apoptotic mechanisms of melatonin on a variety of tumor cells.

Original languageEnglish
Pages (from-to)58-65
Number of pages8
JournalMalaysian Journal of Biochemistry and Molecular Biology
Issue number3
Publication statusPublished - 2019


  • Apoptosis
  • Cancer
  • Melatonin

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