The prevalence of sarcopenia and relationships between muscle and bone in ageing West-African Gambian men and women

Ayse Zengin, Landing M. Jarjou, Ann Prentice, Cyrus Cooper, Peter R. Ebeling, Kate A. Ward

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: The rapidly rising ageing population in low and middle-income countries (LMIC) will lead to a concurrent increase in musculoskeletal diseases. Sarcopenia is a disease caused by progressive loss of skeletal muscle mass and strength, leading to adverse outcomes including frailty, falls, fractures, and premature mortality. We investigated the prevalence of sarcopenia, assessed the suitability of current diagnostic guidelines and explored muscle–bone relationships in ageing men and women from rural Gambia. Methods: A total of 249 women and 239 men aged 40–75+ years were recruited. Body composition was measured using dual energy X-ray absorptiometry. Comparisons of the Foundations for the National Institutes of Health (FNIH) and European Working Group On Sarcopenia (EWGSOP) definitions of sarcopenia to define prevalence and to identify poor physical capability were determined. Functional ability was assessed by jumping mechanography to calculate lower limb muscle force and power; grip strength was assessed by a hand dynamometer. Peripheral quantitative computed tomography was used to assess muscle–bone relationships. Results: The prevalence of sarcopenia in Gambian men and women significantly varied depending on the definition used; in men 20% and 19% and in women 45% and 10% for FNIH and EWGSOP, respectively. The FNIH appendicular lean mass cut-off had greatest sensitivity and specificity in identifying low functional ability in Gambian adults. Muscle force was positively associated with measures of tibial bone size, strength, and mineral content. Conclusions: The variation in the prevalence of sarcopenia depends on the definition used and highlights the importance of measuring functional capability across ethnic populations.

Original languageEnglish
Pages (from-to)920-928
Number of pages9
JournalJournal of Cachexia, Sarcopenia and Muscle
Volume9
Issue number5
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • Ageing
  • Bone
  • Ethnicity
  • Jumping mechanography
  • Muscle
  • Sarcopenia

Cite this

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title = "The prevalence of sarcopenia and relationships between muscle and bone in ageing West-African Gambian men and women",
abstract = "Background: The rapidly rising ageing population in low and middle-income countries (LMIC) will lead to a concurrent increase in musculoskeletal diseases. Sarcopenia is a disease caused by progressive loss of skeletal muscle mass and strength, leading to adverse outcomes including frailty, falls, fractures, and premature mortality. We investigated the prevalence of sarcopenia, assessed the suitability of current diagnostic guidelines and explored muscle–bone relationships in ageing men and women from rural Gambia. Methods: A total of 249 women and 239 men aged 40–75+ years were recruited. Body composition was measured using dual energy X-ray absorptiometry. Comparisons of the Foundations for the National Institutes of Health (FNIH) and European Working Group On Sarcopenia (EWGSOP) definitions of sarcopenia to define prevalence and to identify poor physical capability were determined. Functional ability was assessed by jumping mechanography to calculate lower limb muscle force and power; grip strength was assessed by a hand dynamometer. Peripheral quantitative computed tomography was used to assess muscle–bone relationships. Results: The prevalence of sarcopenia in Gambian men and women significantly varied depending on the definition used; in men 20{\%} and 19{\%} and in women 45{\%} and 10{\%} for FNIH and EWGSOP, respectively. The FNIH appendicular lean mass cut-off had greatest sensitivity and specificity in identifying low functional ability in Gambian adults. Muscle force was positively associated with measures of tibial bone size, strength, and mineral content. Conclusions: The variation in the prevalence of sarcopenia depends on the definition used and highlights the importance of measuring functional capability across ethnic populations.",
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The prevalence of sarcopenia and relationships between muscle and bone in ageing West-African Gambian men and women. / Zengin, Ayse; Jarjou, Landing M.; Prentice, Ann; Cooper, Cyrus; Ebeling, Peter R.; Ward, Kate A.

In: Journal of Cachexia, Sarcopenia and Muscle, Vol. 9, No. 5, 01.10.2018, p. 920-928.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The prevalence of sarcopenia and relationships between muscle and bone in ageing West-African Gambian men and women

AU - Zengin, Ayse

AU - Jarjou, Landing M.

AU - Prentice, Ann

AU - Cooper, Cyrus

AU - Ebeling, Peter R.

AU - Ward, Kate A.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background: The rapidly rising ageing population in low and middle-income countries (LMIC) will lead to a concurrent increase in musculoskeletal diseases. Sarcopenia is a disease caused by progressive loss of skeletal muscle mass and strength, leading to adverse outcomes including frailty, falls, fractures, and premature mortality. We investigated the prevalence of sarcopenia, assessed the suitability of current diagnostic guidelines and explored muscle–bone relationships in ageing men and women from rural Gambia. Methods: A total of 249 women and 239 men aged 40–75+ years were recruited. Body composition was measured using dual energy X-ray absorptiometry. Comparisons of the Foundations for the National Institutes of Health (FNIH) and European Working Group On Sarcopenia (EWGSOP) definitions of sarcopenia to define prevalence and to identify poor physical capability were determined. Functional ability was assessed by jumping mechanography to calculate lower limb muscle force and power; grip strength was assessed by a hand dynamometer. Peripheral quantitative computed tomography was used to assess muscle–bone relationships. Results: The prevalence of sarcopenia in Gambian men and women significantly varied depending on the definition used; in men 20% and 19% and in women 45% and 10% for FNIH and EWGSOP, respectively. The FNIH appendicular lean mass cut-off had greatest sensitivity and specificity in identifying low functional ability in Gambian adults. Muscle force was positively associated with measures of tibial bone size, strength, and mineral content. Conclusions: The variation in the prevalence of sarcopenia depends on the definition used and highlights the importance of measuring functional capability across ethnic populations.

AB - Background: The rapidly rising ageing population in low and middle-income countries (LMIC) will lead to a concurrent increase in musculoskeletal diseases. Sarcopenia is a disease caused by progressive loss of skeletal muscle mass and strength, leading to adverse outcomes including frailty, falls, fractures, and premature mortality. We investigated the prevalence of sarcopenia, assessed the suitability of current diagnostic guidelines and explored muscle–bone relationships in ageing men and women from rural Gambia. Methods: A total of 249 women and 239 men aged 40–75+ years were recruited. Body composition was measured using dual energy X-ray absorptiometry. Comparisons of the Foundations for the National Institutes of Health (FNIH) and European Working Group On Sarcopenia (EWGSOP) definitions of sarcopenia to define prevalence and to identify poor physical capability were determined. Functional ability was assessed by jumping mechanography to calculate lower limb muscle force and power; grip strength was assessed by a hand dynamometer. Peripheral quantitative computed tomography was used to assess muscle–bone relationships. Results: The prevalence of sarcopenia in Gambian men and women significantly varied depending on the definition used; in men 20% and 19% and in women 45% and 10% for FNIH and EWGSOP, respectively. The FNIH appendicular lean mass cut-off had greatest sensitivity and specificity in identifying low functional ability in Gambian adults. Muscle force was positively associated with measures of tibial bone size, strength, and mineral content. Conclusions: The variation in the prevalence of sarcopenia depends on the definition used and highlights the importance of measuring functional capability across ethnic populations.

KW - Ageing

KW - Bone

KW - Ethnicity

KW - Jumping mechanography

KW - Muscle

KW - Sarcopenia

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U2 - 10.1002/jcsm.12341

DO - 10.1002/jcsm.12341

M3 - Article

VL - 9

SP - 920

EP - 928

JO - Journal of Cachexia, Sarcopenia and Muscle

JF - Journal of Cachexia, Sarcopenia and Muscle

SN - 2190-5991

IS - 5

ER -