TY - JOUR
T1 - The prevalence and risk factors of epiretinal membranes
T2 - The Melbourne collaborative cohort study
AU - Aung, Khin Zaw
AU - Makeyeva, Galina A
AU - Adams, Madeleine
AU - Chong, Elaine W
AU - Busija, Lucy
AU - Giles, Graham G
AU - English, Dallas R
AU - Hopper, John L
AU - Baird, Paul N
AU - Guymer, Robyn Heather
AU - Robman, Liubov
PY - 2013
Y1 - 2013
N2 - PURPOSE: To determine the prevalence of epiretinal membranes (ERMs) in Melbourne, Australia and its risk factors in this population. METHODS: The Melbourne Collaborative Cohort Study is a prospective study investigating the role of diet and life style in the causation of common chronic diseases. Eighty-six percent of participants were of Northern European origin born in Australia or United Kingdom and 14 were migrants from Greece or Italy (Southern European origin). Nonmydriatic digital retinal photography was implemented at Melbourne Collaborative Cohort Study follow-up. The ERMs were recorded as cellophane macular reflex without retinal folds or preretinal macular fibrosis (PMF) with retinal folds. RESULTS: A total of 22,406 participants had retinal photography, 95 (n = 21,241) were eligible for ERM grading. The ERM prevalence were 8.9 (1,882); cellophane macular reflex, 4.9 (1,047); and preretinal macular fibrosis, 3.9 (835). After adjustment for age, sex, level of education, smoking status, level of cholesterol, body mass index, waist-to-hip ratio, waist measurement, blood pressure, diabetes, and stroke, increasing age and Southern European ethnicity was significantly associated with ERMs. Overall, in Southern Europeans, ERMs odd ratio was 1.97 (95 confidence intervals, 1.67-2.31), P <0.001; preretinal macular fibrosis was 1.82 (95 confidence intervals, 1.43-2.31), P <0.001; and cellophane macular reflex was 1.93 (1.57-2.38), P <0.001. CONCLUSION: In an older Australian population, the prevalence of ERMs was 8.9 and was almost two times higher in participants of Southern European origin than Northern European origin.
AB - PURPOSE: To determine the prevalence of epiretinal membranes (ERMs) in Melbourne, Australia and its risk factors in this population. METHODS: The Melbourne Collaborative Cohort Study is a prospective study investigating the role of diet and life style in the causation of common chronic diseases. Eighty-six percent of participants were of Northern European origin born in Australia or United Kingdom and 14 were migrants from Greece or Italy (Southern European origin). Nonmydriatic digital retinal photography was implemented at Melbourne Collaborative Cohort Study follow-up. The ERMs were recorded as cellophane macular reflex without retinal folds or preretinal macular fibrosis (PMF) with retinal folds. RESULTS: A total of 22,406 participants had retinal photography, 95 (n = 21,241) were eligible for ERM grading. The ERM prevalence were 8.9 (1,882); cellophane macular reflex, 4.9 (1,047); and preretinal macular fibrosis, 3.9 (835). After adjustment for age, sex, level of education, smoking status, level of cholesterol, body mass index, waist-to-hip ratio, waist measurement, blood pressure, diabetes, and stroke, increasing age and Southern European ethnicity was significantly associated with ERMs. Overall, in Southern Europeans, ERMs odd ratio was 1.97 (95 confidence intervals, 1.67-2.31), P <0.001; preretinal macular fibrosis was 1.82 (95 confidence intervals, 1.43-2.31), P <0.001; and cellophane macular reflex was 1.93 (1.57-2.38), P <0.001. CONCLUSION: In an older Australian population, the prevalence of ERMs was 8.9 and was almost two times higher in participants of Southern European origin than Northern European origin.
UR - http://dro.deakin.edu.au/view/DU:30061492
U2 - 10.1097/IAE.0b013e3182733f25
DO - 10.1097/IAE.0b013e3182733f25
M3 - Article
SN - 0275-004X
VL - 33
SP - 1026
EP - 1034
JO - RETINA, The Journal of Retinal and Vitreous Diseases
JF - RETINA, The Journal of Retinal and Vitreous Diseases
IS - 5
ER -
