The presence of KIR2DS5 confers protection against adult immune thrombocytopenia

Louise A Seymour, Jamie P Nourse, Pauline Crooks, Leesa F Wockner, Robert J Bird, Huyen A Tran, Maher K Gandhi

Research output: Contribution to journalArticleOther

12 Citations (Scopus)


Immune thrombocytopenia (ITP) is an autoimmune disorder of unknown aetiology, characterised by an isolated low platelet count in the absence of other identifiable causes. Genes influencing activation of the immune system have been identified as influencing predisposition. Killer cell immunoglobulin-like receptors (KIR) control T-cell and natural killer (NK) cell function via inhibitory and activating signalling pathways. The inhibitory KIR2DL3, KIR3DL2 and KIR3DL1 are up-regulated in the T-cells of patients with ITP in remission relative to those with active disease, and an association of KIR2DS2 and KIR2DL2 with ITP has also been reported. No comprehensive KIR analysis in ITP has been reported. We performed genotyping of all currently known KIR genes using sequence specific primer polymerase chain reaction (SSP-PCR) on a cohort of 83 adult patients with ITP (chronic/persistent or relapsed primary ITP identified by defined criteria) and 106 age matched healthy white volunteers. Non-white patients were not included in the analysis. There was an over-representation of KIR2DS3 (known to be in linkage disequilibrium with KIR2DS2 and 2DL2) and under-representation of KIR2DS5 (also protective against other immune mediated disorders) in adult ITP [odds ratio (OR)=0.16, confidence interval (CI) 0.08-0.32, P
Original languageEnglish
Pages (from-to)154 - 160
Number of pages7
JournalTissue Antigens
Issue number3
Publication statusPublished - 2014
Externally publishedYes

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