The preprotein translocase of the outer mitochondrial membrane: Receptors and a general import pore

C. Meisinger, J. Brix, K. Model, N. Pfanner, M. T. Ryan

Research output: Contribution to journalReview ArticleResearchpeer-review

21 Citations (Scopus)


Cytosol-synthesized preproteins destined for the mitochondria are transported across the outer membrane by the translocase of the mitochondrial outer membrane (TOM complex). This dynamic transport machinery call be divided into receptors that recognize preprotein targeting signals and components of the general import pore complex that mediate preprotein transport across the outer membrane. This review focuses on recent studies dealing with the central questions regarding the pore-forming subunits, and architecture and gating of the translocation channel of the outer membrane.

Original languageEnglish
Pages (from-to)817-824
Number of pages8
JournalCellular and Molecular Life Sciences
Issue number9-10
Publication statusPublished - 1 Jan 1999
Externally publishedYes


  • Channel
  • Mitochondria
  • Protein import
  • Protein interaction
  • Translocation

Cite this