The preprotein translocase of the outer mitochondrial membrane: Receptors and a general import pore

C. Meisinger, J. Brix, K. Model, N. Pfanner, M. T. Ryan

Research output: Contribution to journalReview ArticleResearchpeer-review

19 Citations (Scopus)

Abstract

Cytosol-synthesized preproteins destined for the mitochondria are transported across the outer membrane by the translocase of the mitochondrial outer membrane (TOM complex). This dynamic transport machinery call be divided into receptors that recognize preprotein targeting signals and components of the general import pore complex that mediate preprotein transport across the outer membrane. This review focuses on recent studies dealing with the central questions regarding the pore-forming subunits, and architecture and gating of the translocation channel of the outer membrane.

Original languageEnglish
Pages (from-to)817-824
Number of pages8
JournalCellular and Molecular Life Sciences
Volume56
Issue number9-10
DOIs
Publication statusPublished - 1 Jan 1999
Externally publishedYes

Keywords

  • Channel
  • Mitochondria
  • Protein import
  • Protein interaction
  • Translocation

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