The predictive value of antral follicle count remains unchanged across the menstrual cycle

Luk Rombauts, Joseph Onwude, Hong Chew, Beverley Vollenhoven

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)


To explore whether the predictive value of antral follicle count (AFC) changes when measured at different times during the menstrual cycle. Antima??ullerian hormone (AMH) and AFC are considered to be equally predictive of poor ovarian response; however, AMH is considered to have an advantage over AFC, because AMH concentrations can be measured at any time during the menstrual cycle. Design: Retrospective cohort study. Setting: Private IVF clinic. Patient(s): A total of 3,117 patients with a transvaginal ultrasound within 3 months before their first IVF cycle. Intervention(s): None. Main Outcome Measure(s): Receiver operating curves (ROCs) were constructed for AFC as a screening test for poor ovarian response (fewer than four eggs collected). The areas under the curve (AUCs) were ompared for ROCs from patients at different phases of the cycle. Result(s): When all patients except those with polycystic ovaries were included, the AUC was 0.79. Further subgroup ROC analyses revealed that the AUCs did not differ significantly when AFC was measured at different phases of the menstrual cycle. Conclusion(s): AFC can be measured regardless of the phase of the menstrual cycle without apparent effect on its predictive value for poor ovarian response. (Fertil Steril 2011;96:1514a??8. 2011 by American Society for Reproductive Medicine.)
Original languageEnglish
Pages (from-to)1514 - 1518
Number of pages5
JournalFertility and Sterility
Issue number6
Publication statusPublished - 2011

Cite this