TY - JOUR
T1 - The potential role of activin and follistatin in lung transplant dysfunction
AU - Snell, John N
AU - Westall, Glen Philip
AU - Snell, Gregory I
PY - 2015
Y1 - 2015
N2 - Activin A, a member of the transforming growth factor ? super-family, is a key regulator of multiple biological pathways including the physiological processes of organ development and homeostasis; as well as the pathological processes of inflammation, remodelling and fibrosis. Dysregulation of activin A and its naturally occurring antagonist follistatin, contribute to the development of disease in multiple organ systems. In this review, we summarize the regulation of activin A, its dysregulated expression in a number of respiratory diseases and postulate its potential role in contributing to allograft dysfunction following lung transplantation.
AB - Activin A, a member of the transforming growth factor ? super-family, is a key regulator of multiple biological pathways including the physiological processes of organ development and homeostasis; as well as the pathological processes of inflammation, remodelling and fibrosis. Dysregulation of activin A and its naturally occurring antagonist follistatin, contribute to the development of disease in multiple organ systems. In this review, we summarize the regulation of activin A, its dysregulated expression in a number of respiratory diseases and postulate its potential role in contributing to allograft dysfunction following lung transplantation.
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-84949093212&origin=inward&txGid=0
U2 - 10.1586/17476348.2015.1098537
DO - 10.1586/17476348.2015.1098537
M3 - Article
SN - 1747-6348
VL - 9
SP - 697
EP - 701
JO - Expert Review of Respiratory Medicine
JF - Expert Review of Respiratory Medicine
IS - 6
ER -