The potential role of activin and follistatin in lung transplant dysfunction

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Activin A, a member of the transforming growth factor ? super-family, is a key regulator of multiple biological pathways including the physiological processes of organ development and homeostasis; as well as the pathological processes of inflammation, remodelling and fibrosis. Dysregulation of activin A and its naturally occurring antagonist follistatin, contribute to the development of disease in multiple organ systems. In this review, we summarize the regulation of activin A, its dysregulated expression in a number of respiratory diseases and postulate its potential role in contributing to allograft dysfunction following lung transplantation.
Original languageEnglish
Pages (from-to)697 - 701
Number of pages5
JournalExpert Review of Respiratory Medicine
Issue number6
Publication statusPublished - 2015

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