The Potential of Gonadal Hormone Signalling Pathways as Therapeutics for Dementia

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Abstract

Dementia is an ever-expanding problem facing an ageing society. Currently, there is a sharp paucity of treatment strategies. It has long been known that sex hormones, namely 17β-estradiol and testosterone, possess neuroprotective- and cognitive-enhancing qualities. However, certain lacunae in the knowledge underlying their molecular mechanisms have delayed their use as treatment strategies in dementia. With recent advancements in pharmacology and molecular biology, especially in the development of safer selective oestrogen receptor modulators and the recent discovery of the small-molecule brain-derived neurotrophic factor receptor agonist, 7,8-dihydroxyflavone, the exploitation of these signalling pathways for clinical use has become possible. This review aims to adumbrate the evidence and hurdles underscoring the use of sex hormones in the treatment of dementia as well as discussing some direction that is required to advance the translation of evidence into practise.

Original languageEnglish
Pages (from-to)336-348
Number of pages13
JournalJournal of Molecular Neuroscience
Volume60
Issue number3
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • 7,8-DHF
  • Alzheimer’s disease
  • BDNF
  • Cognition
  • Dementia
  • Estradiol
  • Raloxifene
  • Sex hormones
  • Testosterone
  • TrkB

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