The potential of carnosine in brain-related disorders: A comprehensive review of current evidence

Martin Schön, Aya Mousa, Michael Berk, Wern L. Chia, Jozef Ukropec, Arshad Majid, Barbara Ukropcová, Barbora De Courten

Research output: Contribution to journalReview ArticleResearchpeer-review

18 Citations (Scopus)


Neurological, neurodegenerative, and psychiatric disorders represent a serious burden because of their increasing prevalence, risk of disability, and the lack of effective causal/disease-modifying treatments. There is a growing body of evidence indicating potentially favourable effects of carnosine, which is an over-the-counter food supplement, in peripheral tissues. Although most studies to date have focused on the role of carnosine in metabolic and cardiovascular disorders, the physiological presence of this di-peptide and its analogues in the brain together with their ability to cross the blood-brain barrier as well as evidence from in vitro, animal, and human studies suggest carnosine as a promising therapeutic target in brain disorders. In this review, we aim to provide a comprehensive overview of the role of carnosine in neurological, neurodevelopmental, neurodegenerative, and psychiatric disorders, summarizing current evidence from cell, animal, and human cross-sectional, longitudinal studies, and randomized controlled trials.

Original languageEnglish
Article number1196
Number of pages26
Issue number6
Publication statusPublished - Jun 2019


  • Brain
  • Carnosine
  • Cognition
  • L-histidine
  • Nervous system
  • Neurology
  • Psychiatry
  • Treatment
  • β-alanine

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