Abstract
Mild traumatic brain injury (mTBI) is a common health problem. There is tremendous variability and heterogeneity in human mTBI, including mechanisms of injury, biomechanical forces, injury severity, spatial and temporal pathophysiology, genetic factors, pre-injury vulnerability and resilience factors, and clinical outcomes. Animal models greatly reduce this variability and heterogeneity, and provide a means to study mTBI in a rigorous, controlled, and efficient manner. Rodent models, in particular, are time- and cost-efficient, and they allow researchers to measure morphological, cellular, molecular, and behavioral variables in a single study. However, inter-species differences in anatomy, morphology, metabolism, neurobiology, and lifespan create translational challenges. Although the term “mild” TBI is used often in the pre-clinical literature, clearly defined criteria for mild, moderate, and severe TBI in animal models have not been agreed upon. In this review, we introduce current issues facing the mTBI field, summarize the available research methodologies and previous studies in mTBI animal models, and discuss how a translational research approach may be useful in advancing our understanding and management of mTBI.
| Original language | English |
|---|---|
| Pages (from-to) | 396-414 |
| Number of pages | 19 |
| Journal | Neuroscience and Biobehavioral Reviews |
| Volume | 76 |
| DOIs | |
| Publication status | Published - 1 May 2017 |
| Externally published | Yes |
Keywords
- Biomarker
- Clinical
- Concussion
- Pre-clinical
- Review
- Translational research
- Treatment
Cite this
}
The potential for animal models to provide insight into mild traumatic brain injury : Translational challenges and strategies. / Shultz, Sandy R.; McDonald, Stuart J.; Vonder Haar, Cole; Meconi, Alicia; Vink, Robert; van Donkelaar, Paul; Taneja, Chand; Iverson, Grant L.; Christie, Brian R.
In: Neuroscience and Biobehavioral Reviews, Vol. 76, 01.05.2017, p. 396-414.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - The potential for animal models to provide insight into mild traumatic brain injury
T2 - Translational challenges and strategies
AU - Shultz, Sandy R.
AU - McDonald, Stuart J.
AU - Vonder Haar, Cole
AU - Meconi, Alicia
AU - Vink, Robert
AU - van Donkelaar, Paul
AU - Taneja, Chand
AU - Iverson, Grant L.
AU - Christie, Brian R.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Mild traumatic brain injury (mTBI) is a common health problem. There is tremendous variability and heterogeneity in human mTBI, including mechanisms of injury, biomechanical forces, injury severity, spatial and temporal pathophysiology, genetic factors, pre-injury vulnerability and resilience factors, and clinical outcomes. Animal models greatly reduce this variability and heterogeneity, and provide a means to study mTBI in a rigorous, controlled, and efficient manner. Rodent models, in particular, are time- and cost-efficient, and they allow researchers to measure morphological, cellular, molecular, and behavioral variables in a single study. However, inter-species differences in anatomy, morphology, metabolism, neurobiology, and lifespan create translational challenges. Although the term “mild” TBI is used often in the pre-clinical literature, clearly defined criteria for mild, moderate, and severe TBI in animal models have not been agreed upon. In this review, we introduce current issues facing the mTBI field, summarize the available research methodologies and previous studies in mTBI animal models, and discuss how a translational research approach may be useful in advancing our understanding and management of mTBI.
AB - Mild traumatic brain injury (mTBI) is a common health problem. There is tremendous variability and heterogeneity in human mTBI, including mechanisms of injury, biomechanical forces, injury severity, spatial and temporal pathophysiology, genetic factors, pre-injury vulnerability and resilience factors, and clinical outcomes. Animal models greatly reduce this variability and heterogeneity, and provide a means to study mTBI in a rigorous, controlled, and efficient manner. Rodent models, in particular, are time- and cost-efficient, and they allow researchers to measure morphological, cellular, molecular, and behavioral variables in a single study. However, inter-species differences in anatomy, morphology, metabolism, neurobiology, and lifespan create translational challenges. Although the term “mild” TBI is used often in the pre-clinical literature, clearly defined criteria for mild, moderate, and severe TBI in animal models have not been agreed upon. In this review, we introduce current issues facing the mTBI field, summarize the available research methodologies and previous studies in mTBI animal models, and discuss how a translational research approach may be useful in advancing our understanding and management of mTBI.
KW - Biomarker
KW - Clinical
KW - Concussion
KW - Pre-clinical
KW - Review
KW - Translational research
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=84992313142&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2016.09.014
DO - 10.1016/j.neubiorev.2016.09.014
M3 - Review Article
C2 - 27659125
AN - SCOPUS:84992313142
VL - 76
SP - 396
EP - 414
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
ER -