The potential for animal models to provide insight into mild traumatic brain injury: Translational challenges and strategies

Sandy R. Shultz, Stuart J. McDonald, Cole Vonder Haar, Alicia Meconi, Robert Vink, Paul van Donkelaar, Chand Taneja, Grant L. Iverson, Brian R. Christie

Research output: Contribution to journalReview ArticleResearchpeer-review

70 Citations (Scopus)

Abstract

Mild traumatic brain injury (mTBI) is a common health problem. There is tremendous variability and heterogeneity in human mTBI, including mechanisms of injury, biomechanical forces, injury severity, spatial and temporal pathophysiology, genetic factors, pre-injury vulnerability and resilience factors, and clinical outcomes. Animal models greatly reduce this variability and heterogeneity, and provide a means to study mTBI in a rigorous, controlled, and efficient manner. Rodent models, in particular, are time- and cost-efficient, and they allow researchers to measure morphological, cellular, molecular, and behavioral variables in a single study. However, inter-species differences in anatomy, morphology, metabolism, neurobiology, and lifespan create translational challenges. Although the term “mild” TBI is used often in the pre-clinical literature, clearly defined criteria for mild, moderate, and severe TBI in animal models have not been agreed upon. In this review, we introduce current issues facing the mTBI field, summarize the available research methodologies and previous studies in mTBI animal models, and discuss how a translational research approach may be useful in advancing our understanding and management of mTBI.

Original languageEnglish
Pages (from-to)396-414
Number of pages19
JournalNeuroscience and Biobehavioral Reviews
Volume76
DOIs
Publication statusPublished - 1 May 2017
Externally publishedYes

Keywords

  • Biomarker
  • Clinical
  • Concussion
  • Pre-clinical
  • Review
  • Translational research
  • Treatment

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